The common heterocyclic compound, 213265-83-9, name is 4,6-Dichloro-5-fluoropyrimidine, molecular formula is C4HCl2FN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 213265-83-9
0.2 g of 4,6-dichloro-5-fluoropyrimidine and 0.41 g of 3,5-dimethylpiperidine (cis/trans diastereomer = about 3/1) were mixed and left for 30 minutes at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0. 1 g of 4-CHLORO-6- (CIS-3, 5-dimethyl piperidino) -5-fluoropyrimidine and 0.05 g of 4-chloro- 6- (TRANS-3, 5-dimethylpiperidino) pyrimidin. cis diastereomer: H-NMR : 0.84 (dd, 1H), 0.93 (d, 6H), 1.64-1. 78 (m, 2H), 1.84-1. 92 (m, 1H), 2.46 (dd, 2H), 4.48 (d, 2H), 8. 11 (s, 1H) trans diastereomer: H-NMR : 0.96 (d, 6H), 1.51 (t, 2H), 1.96-2. 06 (m, 2H), 3.40 (dd, 2H), 3.83 (dd, 2H), 8. 10 (s, 1H)
The synthetic route of 213265-83-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2004/99160; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia