In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20781-06-0, name is 2,4-Diaminopyrimidine-5-carboxaldehyde, the common compound, a new synthetic route is introduced below. SDS of cas: 20781-06-0
EXAMPLE 109 6-Pyridin-4-yl-pyrido[2,3-d]pyrimidine-2,7-diamine To cooled (0 C.) 2-ethoxyethanol (13 mL) was added portionwise 0.30 g of sodium hydride (60% in mineral oil), and the suspension was stirred for 10 minutes. To this suspension was added 1.06 g of 4-pyridylaceto-nitrile hydrochloride, and the mixture was stirred at room temperature for 30 minutes. The neutralized solution of 4-pyridylacetonitrile in 2-ethoxyethanol was added to a reaction mixture containing sodium 2-ethoxyethoxide (prepared from 0.11 g of sodium hydride and 4.76 mL of 2-ethoxyethanol) and 0.9 g of 2,4-diamino-5-pyrimidinecarboxaldehyde. The resulting mixture was heated at reflux for 2 hours, cooled, and the insoluble product washed with diethylether and ethyl acetate to afford the title compound; mp >340 C.; MS(CI). Analysis calculated for C12 H10 N6.0.05 H2 O: C, 60.27; H, 4.26; N, 35.14. Found: C, 60.35; H, 4.31; N, 34.75.
The synthetic route of 20781-06-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Blankley; Clifton John; Doherty; Annette Marian; Hamby; James Marino; Panek; Robert Lee; Schroeder; Mel Conrad; Showalter; Howard Daniel Hollis; Connolly; Cleo; US5733913; (1998); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia