Reference of 2565-47-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2565-47-1, name is 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, molecular formula is C5H6N2O3, molecular weight is 142.1127, as common compound, the synthetic route is as follows.
Phosphoryl chloride (55 ml) is carefully added to barbituric acid (10 g, 78.1 mmol) at 0 C. Water (1.7 ml) is then added dropwise such that the temperature does not exceed 5 C. The mixture is boiled under reflux for 5 h and, after it has cooled down, poured onto ice. The product is extracted with ethyl acetate (3¡Á100 ml) and dried (Na2 SO4). The mixture is filtered and the solvent is distilled off in vacuo.
The chemical industry reduces the impact on the environment during synthesis 2565-47-1, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Aventis Pharma Deutschland GmbH; US2004/242583; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia