Brief introduction of 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole

The chemical industry reduces the impact on the environment during synthesis 1032452-86-0, I believe this compound will play a more active role in future production and life.

Reference of 1032452-86-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1032452-86-0, name is 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole, molecular formula is C13H10ClN3, molecular weight is 243.69, as common compound, the synthetic route is as follows.

The compound 3- (2-chloro-4-yl) -1-methyl-indole (300mg, 1.23mmol)And methyl 4-amino-2-nitro-5-(trifluoromethoxy)benzoate (257 mg, 1.48 mmol)Into the reaction flask,Then add 1,4-dioxane(10mL),p-Toluenesulfonic acid (254 mg, 1.48 mmol) was added with stirring.Heat to 85C for 10 hoursAfter the reaction is completed,Cool to room temperaturePrecipitation of solids,Filter and filter cake washed with acetonitrileDry to give a yellow solid (460 mg,Yield: 98.08%).

The chemical industry reduces the impact on the environment during synthesis 1032452-86-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Tianjin Binjiang Pharmaceutical Research And Development Co., Ltd.; Tian Hongqi; Huang Gongchao; Cheng Ying; (48 pag.)CN107793413; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
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