Adding a certain compound to certain chemical reactions, such as: 302964-08-5, 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 302964-08-5, blongs to pyrimidines compound. 302964-08-5
To the stirred suspension of compound 5 (10.0 g, 0.03 mol), in n-pentanol (120.0 mL) was added N-Boc piperazine(9.5g, 0.05 mol)) and N,N-diisopropylethylamine (DIPEA) (6.6 g, 0.06 mol) and refluxed for 8h, cooled to 25-30C and charged water (80.0 mL). The precipitated solid was collected by vacuum filtration and washed the wet cake with n-pentanol (15.0 mL) followed by water (30.0 mL), yielded the intermediate 3 (11.6 g, 84%) as off white solid.MR: 293-295C; IR (KBr, cm-1): 3397.4 (N-H), 3061.7 (Ar C-H), 1617.0 (amide C=O); 1706.9 ( Boc C=O); 1HNMR spectrum (400 MHz, DMSO-d6), delta, ppm (J, Hz): 11.53 (bs, 1H, thiazole-NH), 9.89 (s, 1H, amide-NH), 8.23(s, 1H, thiazole-H), 7.40 (d, 1H, J =6.9, Ar-H), 7.30-7.23 (m, 2H, Ar-H), 6.06 (s, 1H, pyrimidine-H), 3.53 (bs, 4H,4piperazine-CH2), 3.42 (bs, 4H, piperazine-CH2), 2.42 (s, 3H, Ar-CH3), 2.24 (s, 3H, pyrimidine-CH3), 1.40 (s, 9H,Boc-CH3); 13C NMR spectrum (100 MHz, DMSO-d6), delta, ppm: 165.2 (pyrimidine-C), 162.4 (pyrimidine-C), 161.9(pyrimidine-C), 160.1 (amide-C), 156.9 (thiazole-C), 151.4 (Boc-C), 140.5 (Ar-C), 139.1 (thiazole-C), 133.7(thiazole-C), 132.0 (Ar-C), 129.5 (Ar-C), 128.4 (Ar-C), 127.6 (Ar-C), 125.1 (pyrimidine-C), 81.6 (pyrimidine-C),80.2 (Boc-C), 50.2 (piperazine-2C), 49.9 (piperazine-2C), 29.1 (Boc-CH3), 25.6 (Ar-CH3), 18.2 (pyrimidine-CH3);HPLC Purity 96.7%; MS (ESI) m/z 544.1 [M + H] +; Anal. Calcd % for C25H30ClN7O3S: C 55.19; H 5.56; N 18.02.Found: C 55.07; H 5.41; N 18.17.
With the rapid development of chemical substances, we look forward to future research findings about 302964-08-5.
Reference:
Article; Suresh, Garbapu; Nadh, Ratnakaram Venkata; Srinivasu, Navuluri; Yennity, Durgaprasad; Synthetic Communications; vol. 47; 17; (2017); p. 1610 – 1621;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia