In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 34415-10-6, name is 2-Methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid, the common compound, a new synthetic route is introduced below. Recommanded Product: 2-Methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid
A mixture of 6-hydroxy-2-methylpyrimidine-4-carboxylic acid (500 mg) and phosphorus oxychloride (5 mL) was heated under reflux under a nitrogen atmosphere for 2 hr. The solvent was evaporated under reduced pressure. To the residue was added THF (3 mL). The reaction mixture was added dropwise to a mixture of 1-(3-fluoro-5-(1-methyl-1H-pyrazol-4-yl)phenyl)methanamine (732 mg), TEA (646 mg) and dichloromethane (8 mL) at 0C over 10 min, and the reaction mixture was stirred at the same temperature for 2 hr. The reaction mixture was diluted with water, and the aqueous layer was extracted with dichloromethane. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give the title compound (198 mg) . MS: [M+H]+ 360.1.
The synthetic route of 34415-10-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Takeda Pharmaceutical Company Limited; HIRAYAMA, Takaharu; HIRATA, Yasuhiro; TOMINARI, Yusuke; IWAMURA, Naoki; SASAKI, Yusuke; ASANO, Moriteru; TAKAGI, Terufumi; OKANIWA,Masanori; YOSHIDA, Masato; ICHIKAWA, Takashi; IMAMURA, Shinichi; (113 pag.)EP3514149; (2019); A1;,
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