The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Piperidin-4-amine dihydrochloride( cas:35621-01-3 ) is researched.SDS of cas: 35621-01-3.Takai, Haruki; Obase, Hiroyuki; Nakamizo, Nobuhiro; Teranishi, Masayuki; Kubo, Kazuhiro; Shuto, Katsuichi; Hashimoto, Tamotsu published the article 《Synthesis and pharmacological evaluation of piperidine derivatives with various heterocyclic rings at the 4-position》 about this compound( cas:35621-01-3 ) in Chemical & Pharmaceutical Bulletin. Keywords: antiulcer antiinflammatory antihypertensive heterocyclylpiperidine preparation; structure activity antihypertensive heterocyclylpiperidine; piperidine heterocyclyl preparation biol activity. Let’s learn more about this compound (cas:35621-01-3).
A series of piperidine derivatives with various heterocyclic rings at the 4-position, e.g. I, II, was prepared and tested for antihypertensive activity and other biol. activities. The antihypertensive effects of the present compounds in the spontaneous hypertensive rat were less potent than those of previously reported compounds However, some exhibited antiulcer and/or antiinflammatory activity. Structure-activity relationships are discussed.
There is still a lot of research devoted to this compound(SMILES：NC1CCNCC1.[H]Cl.[H]Cl)SDS of cas: 35621-01-3, and with the development of science, more effects of this compound(35621-01-3) can be discovered.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia