Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10132-07-7, name is 4-Amino-2,6-dichloropyrimidine. A new synthetic method of this compound is introduced below., Recommanded Product: 4-Amino-2,6-dichloropyrimidine
Amino-2,6-dichloropyrimidine (DCAP, 4 g, 24.4 mmol)Suspended in acetic anhydride (80 mL, 860 mmol) and heated under reflux with stirring for 4 hours.After cooling, the reaction solution was concentrated in vacuo and the remaining acetic anhydride was removed by distillation after adding toluene.The residue was dissolved in ethyl acetate and water, and 10% NaHCO3 solution was added until the solution had a pH of 7.The organic layer was washed with saturated brine and the solvent was dissolved. The residue was dissolved in acetic anhydride (40 mL) and stirred at 0-5 C for 2 hours. The precipitate was collected by filtration and dried in vacuo at 40 C to afford intermediate (A). MS m / z (ESI): 206.0 [M + 1] +.
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Reference:
Patent; Shanghai Zhaoyu Pharmaceutical Technology Co., Ltd.; Zhong Yan; Cao Xirong; Wang Yonglin; (21 pag.)CN107286146; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia