In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 60025-09-4, name is 4-Amino-6-chloropyrimidine-5-carbonitrile, the common compound, a new synthetic route is introduced below. Recommanded Product: 4-Amino-6-chloropyrimidine-5-carbonitrile
Step 3. Preparation of 4-Amino-5-cyano-6-(((8-chloro-2-phenyl-1,4-dihydroquinolin-3-yl) methyl) amino) pyrimidine 3-Aminomethyl-2-phenylquinolin-4(1H)-one (1.25g, 0.005mol) and 50ml of isopropanol were added to a 100ml three-necked flask and stirred to be dissolved. 4-amino-5-cyano-6-chloropyrimidine (0.93g, 0.006mol) and potassium carbonate (2.1g, 0.015mol) were then added; the temperature was raised to 80C and reaction was carried out under reflux for 5h with stirring. TLC tracking was performed until the completion of the reaction. The reaction was stopped and suction filtration was performed. The filter cake was washed with a large amount of ethyl acetate; solvent was removed under reduced pressure; and methanol and silica gel were added to the residue for preparing a mixture for chromatography. After column chromatography separation, 1.37g of a white solid was obtained with a yield of 68.1 %. 1H NMR (500MHz, DMSO-d6) delta: 10.80(s, 1H), 8.18?8.17(d, 1H, J=5.0Hz), 7.88?7.87(d, 1H, J=5.0Hz), 7.56?7.54(m, 5H), 7.36?7.39(t, 1H, J=7.5Hz), 6.4 3(s, 3H), 6.10(s, 2H), 4.23(s, 2H). ES: m/z 368.9[M+H]+.
The synthetic route of 60025-09-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nanjing Sanhome Pharmaceutical Co., Ltd.; WANG, Yong; LIU, Xiaorong; HUANG, Dandan; ZHANG, Yan; KAI, Yumei; (47 pag.)EP3266774; (2018); A1;,
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