Adding a certain compound to certain chemical reactions, such as: 49844-90-8, 4-Chloro-2-(methylthio)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 49844-90-8, blongs to pyrimidines compound. Formula: C5H5ClN2S
A mixture of 4-chloro-2-(methylsulfanyl)pyrimidine (2 g, 12.45 mmol), (2,6- difluoro-4-pyridyl)boronic acid (3.95 g, 24.90 mmol) , Cs2C03 (8.11 g, 24.90 mmol) and (dppf)PdCl2-DCM (1.07 g, 1.24 mmol) in water (15 mL) and MeCN (45 mL) was degassed with N2, capped in a glass reaction tube (150 mL), heated at 95 C for 2.5 h. After cooled, it was filtered through a short pad of CELITE, diluted with water, extracted with EtOAc (2 x 80 mL), dried (Na2S04), filtered and concentrated on CELITE. The crude product was purified by Si02 chromatography (ISCO 40 g column) and eluded with an EtOAc/heptane gradient (0 to 15% EtOAc) to afford 2.66 g (89%) of 4-(2,6-difluoropyridin-4-yl)-2- (methylthio)pyrimidine as white solid. MS: m/z 239.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,49844-90-8, its application will become more common.
Reference:
Patent; GENENTECH, INC.; KOLESNIKOV, Aleksandr; DO, Steven; WO2015/85007; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia