Adding a certain compound to certain chemical reactions, such as: 39876-88-5, 4-Chlorobenzofuro[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines
First of all, 2.42 g of 4-chlorobenzofuran [3, 2-d]pyrimidine, 2.19 g of phenylboronic acid, 1.89 g of sodium carbonate, 0.10 g of bis(triphenylphosphine)palladium chloride(II) (abbreviation: Pd(PPh3)2Cl2), 20 mL of water and 201 mL of acetonitrile were placed in an eggplant type flask equipped with a reflux tube, and the interior of the flask was replaced with argon gas. The reaction vessel was irradiated with microwaves (2.45 GHz, 100 W) for 60 minutes to heat. Then, the obtained residue was filtered with water and washed with hexane. With hexane: The obtained solid was purified by flash column chromatography of ethyl acetate = 2:1 to eluent solvent to give the desired pyrimidine derivative Hpbf pm (white powder, yield 45%). Further, microwaves were irradiated using a microwave synthesizer (manufactured by CEM Corporation, Discover).
The synthetic route of 39876-88-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Co., Ltd. Semiconductor Energies Institute; Jing Shangyingzi; Shan Kouzhiye; Lai Weiguangmei; Lai Weizheshi; (69 pag.)CN103450279; (2018); B;,
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