Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 42212-19-1, name is 6-Amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)-dione. A new synthetic method of this compound is introduced below., Safety of 6-Amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)-dione
In a microwave reaction vessel at room temperature 6-amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)dione (217.2 mg, 1.0 mmol) and phenyl isocyanate (142.9 mg, 1.2 mmol) was dissolved in nitrobenzene (1 ml). The reaction mixture was allowed to react for 10 to 20 minutes under microwave conditions at 210 . After completion of the reaction was evaporated under reduced pressure and the reaction mixture transferred to a round bottom flask. Hexane and ethyl acetate was purified by silica gel column chromatography to give the titled compound the reaction mixture concentrated to a 6-amino-3-methyl-2,4-oxo Using -N, diphenyl-1,2,3,4-1- to give a tetra hydro-pyrimidine-5-carboxamide (282.5mg, 84%).
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Reference:
Patent; Dongguk University Academic Cooperation; Chung-Ang University Academic Cooperation; Kong, Young Dae; Min, Kyung Hoon; Yang, Sung Joo; Song, Ji HO; (38 pag.)KR2016/106837; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
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