Adding a certain compound to certain chemical reactions, such as: 98141-42-5, 4,6-Dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 4,6-Dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine, blongs to pyrimidines compound. name: 4,6-Dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
To a stirred solution of (rac)-(2S,4R,6S,7S)-methyl 7-aminotricyclo[3.2.2.02,4]nonane-6-carboxylate (3.4 g, 17.4 mmol) in THF (150 ml) was added 4,6-dichloro-1-methyi-1Hpyrazolo[3,4-d]pyrimidine (4.24 g, 20.9 mmol) and (3.38 g, 4.52 ml, 26.1 mmol) at roomtemperature and the resulting reaction mixture solution was stirred at 60 oc for 16 h. After cooling to room temperature, the reaction mixture was poured into water (1 00 ml) andextracted with EtOAc (150 ml twice). The combined organic layers were washed with brine,dried over anhydrous Na2S04 , filtered and concentrated in vacuo to give a crude product,which was purified by silica gel flash chromatography (0-1 00% EtOAc-hexane gradient) toafford the title racemic compound (4.1 g, 65.1% yield) as a white solid. MS: 362.0 [M+Ht.
The synthetic route of 98141-42-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SAVIRA PHARMACEUTICALS GMBH; EUROPEAN MOLECULAR BIOLOGY LABORATORY; TAN, Xuefei; ZBINDEN, Katrin Groebke; KUHN, Bernd; WANG, Lisha; LIU, Yongfu; WU, Jun; SHEN, Hong; SHI, Tianlai; (174 pag.)WO2017/133664; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
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