Application of 425394-89-4 , The common heterocyclic compound, 425394-89-4, name is 4,6-Dichloropyrimidin-5-ol, molecular formula is C4H2Cl2N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of No.31 4-(hydroxymethyl)cyclohexan-1-ol (0.237 g, 1.82 mmol) in No.13 THF (15 mL) was added No.23 triphenylphosphine (0.718 g, 2.74 mmol) and No.23 4,6-Dichloropyrimidin-5-ol (0.3 g, 1.82 mmol). To the mixture was added No.31 di-tert-butyl azodicarboxylate (0.63 g, 2.74 mmol) at 0C., the mixture was stirred at room temperature for 18 hr. The reaction mixture was concentrated in vacuo. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=9:1 as eluent) to afford the 4-(((4,6-dichloropyrimidin-5-yl)oxy)methyl)cyclohexan-1-ol (0.15 g, 30% yield). LC/MS APCI: Calculated 276.04; Observed m/z [M+H)]+ 277.0.
The synthetic route of 425394-89-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Arrien Pharmaceuticals LLC; Vankayalapati, Hariprasad; US2020/131154; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia