Related Products of 34289-60-6 , The common heterocyclic compound, 34289-60-6, name is 4,6-Dimethylpyrimidin-2-ol hydrochloride, molecular formula is C6H9ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: An equimolar mixture (0.0125 mol) of 2-hydroxypyrimidines 1-2 and a corresponding arylcarboxaldehyde in 80 ml of ethanol was stirred for about 15min and then treated with 2.5 mL of HCl (cc). The obtained reaction mixture was heated under reflux for 6 h togive the corresponding hydrochlorides as red solids, which were then neutralized by 10% aqueous-alcoholic solution of carbonate of potassium. The resulting products (yellow solids) were filtered off, washed by hotethanol and dried in the air.
The synthetic route of 34289-60-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Komissarova, Ekaterina A.; Sosnin, Evgenii; Shklyaeva, Elena V.; Osorgin, Irina V.; Abashev, Georgii G.; Arkivoc; vol. 2017; 3; (2017); p. 105 – 120;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia