Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine. A new synthetic method of this compound is introduced below., 49845-33-2
solution of 2, 4-dichloro-5-nitro pyrimidine (7.26g, 37.4mmol) in THF (100 ml) is cooled to -78 oC. A solution of methyl amine (8M in methanol, 9.35 ml, 74.8 mmol) is added dropwise. The mixture is allowed to warm to room temp and concentrated. The residue is partitioned between ethylacetate and water. The layer is separated and the aqueous layer is extracted with ethylacetate. The combined organic extracts are washed with brine, dried over Na2SO4, filtered and concentrated to afford the title product (7.0 g) (Note: The product contains 5percent regio-isomer, 4-chloro-2-(methylamino)-5-nitropyrimidine). The residue is used in the next step without further purification. mp: 86-87 OC; 1H NMR (300 MHz, CDCl3): delta 9.06 (s, 1H), 8.43 (brs, 1H), 3.25 (d, J = 5.12 Hz, 3H) ppm; m/z=189 (M+).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,49845-33-2, 2,4-Dichloro-5-nitropyrimidine, and friends who are interested can also refer to it.
Reference:
Article; Sadanandam; Jyothi; Adharvana Chari; Das, Parthasarathi; Mukkanti; Tetrahedron Letters; vol. 52; 42; (2011); p. 5521 – 5524;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia