Adding a certain compound to certain chemical reactions, such as: 36082-50-5, 5-Bromo-2,4-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 5-Bromo-2,4-dichloropyrimidine, blongs to pyrimidines compound. Safety of 5-Bromo-2,4-dichloropyrimidine
f) Production of methyl-N-(5-bromo-2-chloropyrimidin-4-yl)-D-alaninate 22.8 g (100 mmol) of 5-bromo-2,4-dichloropyrimidine and 14.0 g (100 mmol) of D-alanic acid methyl ester hydrochloride are dissolved in 300 ml of THF and 75 ml of DMF. The ice-cooled batch is mixed with 33.5 ml (240 mmol) of triethylamine and then slowly heated to room temperature. After 48 hours, the solvent is drawn off in a rotary evaporator, and the remaining residue is purified by chromatography (hexane/ethyl acetate: 4:1 – 2:1). 25.5 g (86.1 – mmol, corresponding to 86% of theory) of the product is obtained. 1H-NMR (CDCl3): 8.2 (s, 1 H), 6.1 (d, 1 H), 4.8 (m, 1 H), 3.8 (s, 3H), 1.6 (d, 3H).
The synthetic route of 36082-50-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Schering Aktiengesellschaft; EP1705177; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia