Reference of 55583-59-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55583-59-0, name is 2,5-Diamino-4,6-dichloropyrimidine, molecular formula is C4H4Cl2N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In the reaction vessel,4,6-Dichloropyrimidine-2,5-diamine(1.00 g, 5.59 mmol), phenylboronic acid(0.681 g, 5.59 mmol), sodium carbonate(2.96 g, 27.9 mmol), and tetrakis(Triphenylphosphine) palladium (0) (323 mg, 0.279 mmol) in toluene (56 mL),Ethanol (14 mL) and distilled water (14 mL)The reaction mixture was cooled to room temperature after stirring for 20 hours under heating reflux conditions under argon atmosphere.Distilled water (6 mL) was added and stirred, and the separated aqueous layer was extracted three times with ethyl acetate (20 mL). Thereafter, the total amount of organic layers is combined, saturated aqueous sodium chloride solution (20 mL) is added thereto, the mixture is stirred for washing, and the separated organic layer is dehydrated by adding anhydrous sodium sulfate,The filtrate after filtration was concentrated under reduced pressure. The concentrate thus obtained is purified by flash column chromatography (silica gel, n-hexane / ethyl acetate),4-Chloro-6-phenylpyrimidine-2,5-diamine was obtained(590 mg, 48% yield).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 55583-59-0, 2,5-Diamino-4,6-dichloropyrimidine.
Reference:
Patent; Microbial Chemistry Research Foundation; Kumagai, Naoya; Noda, Hidetoshi; Asada, Yasuko; Shibazaki, Masakatsu; (48 pag.)JP2019/64981; (2019); A;,
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