Adding a certain compound to certain chemical reactions, such as: 6840-45-5, 3-Bromoimidazo[1,2-a]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6840-45-5, blongs to pyrimidines compound. Product Details of 6840-45-5
A mixture of 4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)pyridin-2-amine (1.0g, 4.54mmol), 3-bromoimidazo[1 ,2-a]pyrimidine (899mg, 4.54mmol) and Na2C03 (963mg, 9.09mmol) in DMF:H20 (3: 1 , 20ml_) was degassed with N2 for 15 min at rt. Pd(PPh3)4 (525mg, 0.45mmol) was added to this degassed mixture at rt. The reaction mixture was again purged with N2 for 5 min. The reaction vessel was sealed and stirred at 90 C for 16h. The TLC showed reaction to be complete. The reaction mixture was allowed to cool to rt and concentrated under reduced pressure. The crude residue was triturated with MeOH (25ml_) and the precipitated solid was filtered through the sintered funnel. The filtrate was concentrated under reduced pressure. The residue was purified by combiflash chromatography using 12g silica column, eluting with 10% MeOH in DCM to afford 4-(imidazo[1 ,2-a]pyrimidin-3- yl)pyridin-2-amine as a brown solid. Yield: 500mg (51 %); MS (ESI+) for CHNOS m/z 212.0[M+H]+; 1 H NMR (400 MHz, DMSO-d6): <5 8.96-9.05 (m, 1 H), 8.55-8.61 (m, 1 H), 8.40 (s, 1 H), 7.94-8.01 (m, 1 H), 6.98-7.15 (m, 3H), 6.05-6.15 (bs, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6840-45-5, its application will become more common.
Reference:
Patent; DISCUVA LTD.; MEO, Paul; KHAN, Nawaz; CHARRIER, Cedric; (252 pag.)WO2019/86890; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia