As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 69034-08-8, name is 5-(Trifluoromethyl)pyrimidin-2-amine, molecular formula is C5H4F3N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C5H4F3N3
To a stirred solution of the mixture A37 and A38(3, 4.5 g, l9.4mmol) in methanol(100 mL) was added drop wise H2S04(10 mL) and the reaction mixture was stirred at 80 C temperature for l6h. After completion of reaction organic solvent was evaporated and the aqueous layer was basified with Sat.NaHCCL up to pH 8 to 9 and aqueous layer was extracted with 10% MeOH in DCM and then concentrated under reduced pressure. The obtained crude was purified by column chromatography using 10% methanol in dichloromethane as eluent to afford methyl 6-(trifluoromethyl)imidazo[l,2- a]pyrimidine-2-carboxylate 1-57 and 1-58 as pink solid Yield: 0.5 g,(10%). LC-MS m/z : 245.97[M+H]+.
With the rapid development of chemical substances, we look forward to future research findings about 69034-08-8.
Reference:
Patent; JUBILANT BIOSYS LIMITED; VADIVELU, Saravanan; RAJAGOPAL, Sridharan; BURRI, Raghunadha Reddy; GARAPATY, Shivani; SIVANANDHAN, Dhanalakshmi; THAKUR, Manish Kumar; NATARAJAN, Tamizharasan; SWAMY, Indu N; NAGARAJU, Nagendra; KANAGARAJ, Subramaniam; MOHD, Zainuddin; SARKAR, Sayantani; SAMANTA, Swapan Kumar; ., Hariprakash; (284 pag.)WO2019/102494; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia