Adding a certain compound to certain chemical reactions, such as: 7752-78-5, 5-Bromo-2-methylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 7752-78-5, blongs to pyrimidines compound. SDS of cas: 7752-78-5
A stirred solution of 5-bromo-2-methylpyrimidine(A18, 0.5 g 2.8 mmol), ethyl 6-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)imidazo[l,2-a]pyridine-2- carboxylate(1-26, 1.55 g, 4.9 mmol) and sodium carbonate(0.612 g, 5.7 mmol) in dioxane : water(4:1) 15 mL was degassed with argon for 20 minutes. Then[I,G- Bis(diphenylphosphino)ferrocene]palladium(II) dichloride(0.126 g, 0.17 mmol) was added. The reaction mixture was heated at 90C for 16 h. After completion, reaction mixture quenched with water and extracted with 20% MeOH in DCM(3 times). The organic layer was separated, dried over anhydrous sodium sulphate and concentrated under reduced pressure to obtain the crude. This crude purified by combiflash using 3% MeOH in DCM as eluent. The desired fractions were concentrated under reduced pressure to offered ethyl 6-(2-methylpyrimidin-5-yl)imidazo[l,2-a]pyridine-2-carboxylate 1-28 as dark solid. Yield: 0.64 g(78%) LC-MS(ES) m/z = 283.3[M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7752-78-5, its application will become more common.
Reference:
Patent; JUBILANT BIOSYS LIMITED; VADIVELU, Saravanan; RAJAGOPAL, Sridharan; BURRI, Raghunadha Reddy; GARAPATY, Shivani; SIVANANDHAN, Dhanalakshmi; THAKUR, Manish Kumar; NATARAJAN, Tamizharasan; SWAMY, Indu N; NAGARAJU, Nagendra; KANAGARAJ, Subramaniam; MOHD, Zainuddin; SARKAR, Sayantani; SAMANTA, Swapan Kumar; ., Hariprakash; (284 pag.)WO2019/102494; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia