Electric Literature of 823-89-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.823-89-2, name is 5-Bromo-2-hydrazinopyrimidine, molecular formula is C4H5BrN4, molecular weight is 189.01, as common compound, the synthetic route is as follows.
A mixture of A-68 (500.00 mg, 2.65 mmol) in CH(OEt)3 (882.54 _1_, 5.30 mmol) was stirred at 120 C for 16 hours The mixture was diluted with EtOH (5 mL) and the solid formed was collected by filtration, washed with EtOH (5 mL x 3) and dried in oven to afford A-71 (400.00 mg, 1.99 mmol) as a solid. H NMR (400MHz, CDC13) _ = 8.81 (s, 1H), 8.68 (d, 1H), 8.62 (d, 1H). LCMS R, = 0.15 min using Method B, MS ESI calcd. for C5H4BrN4 [M+H+2]+ 201.0, found 200.9
Statistics shows that 823-89-2 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-2-hydrazinopyrimidine.
Reference:
Patent; PRAXIS PRECISION MEDICINES, INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; (364 pag.)WO2018/98499; (2018); A1;,
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