Application of 830346-47-9 ,Some common heterocyclic compound, 830346-47-9, molecular formula is C13H10F4N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Bromine (16.5 mL, 0.32 mmol) was added to 1- [2-FLUORO-6- (trifluoromethyl) benzyl] -6-methylpyrimidine-2, 4 (1H, 3H)-DIONE lc (48. 5 g, 0.16 mol) in 145 mL of acetic acid. The resulting mixture became clear then formed precipitate within an hour. After 2 hours stirring, the yellow solid was filtered and washed with cold EtOAc to an almost white solid. The filtrate was washed with sat. NAHC03 and dried over NA2S04. Evaporation gave a yellow solid which was washed with ETOAC to give a light yellow solid. The two solids were combined to give 59.4 g of ld (0.156 mol) total NMR (CDC13) 8 2.422 (s, 3H), 5.478 (s, 2H), 7.246-7. 582 (m, 3H), 8.611 (s, 1H) ; MS (CI) M/Z 380.9 (MH+). 5-Bromo-1-[2, 6-difluorobenzyl]-6-methylpyrimidine-2, 4 (1H, 3H)-dione ld. 1 was made using the same procedure.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 830346-47-9, 1-(2-Fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NEUROCRINE BIOSCIENCES, INC.; WO2005/7164; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia