In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 874-14-6, name is 1,3-Dimethyluracil, the common compound, a new synthetic route is introduced below. category: pyrimidines
General procedure: An 8 mL oven-dried scintillation vial equipped with a magnetic stir bar was charged with a mixture of 4-quinolone or uracil (0.50 mmol, 1.0 equiv), disulfide or thiol (0.75 mmol, 1.5 equiv), molecular iodine (I2) (128 mg, 0.50 mmol, 1.0 equiv), K2S2O8 (1.00-1.50 mmol, 2.0-3.0 equiv), and acetonitrile (CH3CN) (1 mL). The vial was capped, and the reaction mixture was stirred at 60 or 80 C for 12-16 h. Upon completion, saturated Na2S2O3 (5 mL) and distilled deionized H2O (10 mL) was added, and the mixture was extracted with ethyl acetate (3 x 25 mL). The combined organic layer was washed with saturated NaCl, dried over anhydrous Na2SO4, and concentrated in vacuo. The crude product was purified by SiO2 column chromatography to afford the desired thioether products.
The synthetic route of 874-14-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Beukeaw, Danupat; Noikham, Medena; Yotphan, Sirilata; Tetrahedron; vol. 75; 39; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia