Electric Literature of 51940-64-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.51940-64-8, name is Ethyl 2,4-Dichloro-5-pyrimidinecarboxylate, molecular formula is C7H6Cl2N2O2, molecular weight is 221.0407, as common compound, the synthetic route is as follows.
Potassium carbonate (62.50 g, 452.41 mmol) was added to ethyl 2,4-dichloropyrimidine-5-carboxylate (40.00 g, 180.97 mmol) and tetrahydro-2H-pyran-4-amine hydrochloride (24.90 g,10 181.0 mmol) in acetonitrile (1 L). The reaction mixture was stirred at rt for 16 h. The resultingprecipitate was collected by filtration, washed with THF (750 mL) and the combined organic layerswere concentrated in vacuo. The crude product was purified by fcc, elution gradient 0 to 2% THFin DCM, to afford the title compound (37.74 g, 73%) as a pale yellow solid; 1H NMR (400 MHz,DMSO) 1.32 (3H, t), 1.54-1.63 (2H, m), 1.85-1.89 (2H, m), 3.43-3.49 (2H, m), 3.83-3.88 (2H, m),15 4.12-4.26 (lH, m), 4.29-4.34 (2H, m), 8.34 (lH, d), 8.64 (lH, s); m/z MH+ 286.
The chemical industry reduces the impact on the environment during synthesis 51940-64-8, I believe this compound will play a more active role in future production and life.
Reference:
Patent; ASTRAZENECA AB; CANCER RESEARCH TECHNOLOGY LIMITED; FINLAY, Maurice, Raymond, Verschoyle; GOLDBERG, Frederick, Woolf; HOWARD, Martin, Richard; TING, Attilla, Kuan, Tsuei; (145 pag.)WO2019/238929; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia