Brief introduction of Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1224944-77-7, Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference of 1224944-77-7 ,Some common heterocyclic compound, 1224944-77-7, molecular formula is C9H8ClN3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

ompound 4 (2 g, 10.5 mmol) and Compound 7 (2.4 g, 10.5 mmol)Add to n-butanol (50 mL) in turn, then add diisopropylethylamine (10.8 g, 84 mmol).The temperature was raised to 120 C and stirred overnight, and TLC showed that the starting material disappeared.N-butanol is removed under reduced pressure,Water (50 mL) was added to the residue.Extracted with ethyl acetate (50 mL*3).The organic phases were combined and dried over anhydrous magnesium sulfate.Filtration, concentration, silica gel column chromatography (PE: EA = 1:1)Obtained a white solid 8 (3.1 g),The generation rate is 97%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1224944-77-7, Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhengzhou Taijihongnuo Pharmaceutical Co., Ltd.; Wu Yusheng; Zhi Wubin; Li Jingya; Wang Xin; Wu Shiyong; Liang Apeng; Guo Ruiyun; (31 pag.)CN109516999; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia