Reference of 73418-88-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 73418-88-9, name is Methyl 5-aminopyrimidine-2-carboxylate. A new synthetic method of this compound is introduced below.
Methyl 5-aminopyrimidine-2-carboxylate (10.29 mg, 0.067 mmol) and pyridine (0.049 mL, 0.611 mmol) were dissolved in DCM (2 mL) Intermediate 816C (0.030 g, 0.06 1 mmol) was added as a solution in DCM (1 mL). The reaction mixture was allowedto stir for 1 hour. The reaction mixture was concentrated under reduced pressure and purified on ISCO using 24 g column eluting with 0-100% EtOAc over 15 mm to yield Intermediate 816D (24.6 mg, 0.040 mmol, 66.3 % yield) as a pale yellow solid. ?HNIVIR (400MHz, CDC13) 8.47 (d, J=1.8 Hz, 3H), 8.44 (s, 1H), 7.91 (d, J10.3 Hz, 1H), 7.66 (s, 1H), 7.13 (s, 1H), 5.70-5.60 (m, 1H), 5.31 (br. s., 1H), 2.56 (s, 3H), 1.41 (d, J=6.8 Hz,5H), 1.17 (s, 3H), 0.07-0.11 (m, 6H). LC-MS. method H, RT = 1.27 mm, MS (ESI)m/z:608.0 (M+H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,73418-88-9, its application will become more common.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; BATES, J. Alex; HALPERN, Oz Scott; REZNIK, Samuel Kaye; RICHTER, Jeremy M.; (1137 pag.)WO2018/13774; (2018); A1;,
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