Application of 444731-75-3, Adding some certain compound to certain chemical reactions, such as: 444731-75-3, name is N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine,molecular formula is C14H14ClN5, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 444731-75-3.
In the reaction flask, N-(2-chloropyrimidin-4-yl)-N-methyl-2,3-dimethyl-2H-indazole-6-amine29 g and 27 g of potassium carbonate and 19 g of 3-sulfonate amine 4-methyl-aniline were added to 300 mL of ethanol.The reaction was stirred at room temperature for 1.5 h under nitrogen.Then slowly add concentrated hydrochloric acid solution (100mL), after the addition is completed, slowly stir to warm up to reflux state, HPLC monitoringThe residual amount of N-(2-chloropyrimidin-4-yl)-2,3-dimethyl-2H-carbazole-6-amine in the reaction system is less than 1%, and is cooled to about 0 C, and the temperature is kept stirring. 30min,A large amount of solid precipitated under stirring, and the reaction solution was quickly filtered.The filter cake was washed several times with cold ethanol 10 mL.The filter cake was dried to give 36.7 g of pazopanic hydrochloride.
According to the analysis of related databases, 444731-75-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Jinan Ai Si Pharmaceutical Technology Co., Ltd.; Peng Lizeng; Mao Longfei; Liu Xiaofei; Yao Xiaojun; Liu Huanxiang; Bai Qifeng; Liang Lixian; (17 pag.)CN110028495; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
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