As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1450-86-8, name is Pyrimidine-4(3H)-thione, molecular formula is C4H4N2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of Pyrimidine-4(3H)-thione
EXAMPLE 1 4-(N-oxidopyridyl-3-methyl)thiopyrimidine 11.2 g (0.1 moles) 4-mercaptopyrimidine is dissolved in 100 ml ethanol containing 10.8 g sodium methoxide. 18 g (0.1 moles) 3-chloromethylpyridine-N-oxide hydrochloride is added; the mixture is heated under reflux for about one hours. The solution is cooled to ambient temperature, the sodium chloride filtered off, and the filtrate evaporated under vacuum to eliminate the solvent. The residue is crystallized from ethyl acetate to give 15.35 g of product (M.P.=105-108 C.; yield=70%).
With the rapid development of chemical substances, we look forward to future research findings about 1450-86-8.
Reference:
Patent; Poli Industria Chimica S.p.A.; US4224327; (1980); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia