Heterocyclic amplifiers of phleomycin. I. Some pyrimidinylpurines, pyrimidinylpteridines and phenylpyrimidines was written by Brown, Desmond J.;Cowden, William B.;Lan, Shu Bin;Mori, Kenya. And the article was included in Australian Journal of Chemistry in 1984.Synthetic Route of C5H2ClN3 This article mentions the following:
Synthetic routes are described to 5,6-diamino-2,4′-bipyrimidin-4-ones and thence to 2-(pyrimidin-4-yl)purines and 2-(pyrimidin-4-yl)pteridines, some of which bear an S or N-linked basic side chain; also reported are routes to a series of phenyl- and diphenylpyrimidines, with similar S-, N-, or O-linked side chains. Members of all the above systems show activity as amplifiers of phleomycin in a bacterial screen but the phenylpyrimidines with a sulfur-linked side chain are especially active. In the experiment, the researchers used many compounds, for example, 2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4Synthetic Route of C5H2ClN3).
2-Chloropyrimidine-4-carbonitrile (cas: 75833-38-4) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Synthetic Route of C5H2ClN3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia