《Simple pyrimidines. XVI. A synthetic route to some 2-(pyrimidin-2′-yl)acetic acids and esters》 was published in Australian Journal of Chemistry in 1977. These research results belong to Brown, Desmond J.; Waring, Paul. Electric Literature of C8H10N2O2 The article mentions the following:
The pyrimidinylacetic acid derivatives I [R = CO2H, CONH2, C(:NH)OMe, CO2Et, C(:NH)OEt, CN, CO2Me; R1 = H, HO, Cl, MeO, Ph, Me; R2 = H, OH, Cl] were prepared Thus, H2NCOCH2C(:NH)NH2 was treated with PhCOCH2Et to give I (R = CONH2, R1 = Ph, R2 = OH) which with POCl3 gave I (R = CN, R1 = Ph, R2 = Cl). The nitrile was converted into the corresponding imidic ester and then into the carboxylic ester, which underwent dehalogenation to I (R = CO2Me, R1 = Ph, R2 = H) and subsequent hydrolysis to I (R = CO2H, R1 = Ph, R2 = H). After reading the article, we found that the author used Ethyl 2-(pyrimidin-2-yl)acetate(cas: 63155-11-3Electric Literature of C8H10N2O2)
Ethyl 2-(pyrimidin-2-yl)acetate(cas: 63155-11-3) is a member of pyrimidine. Pyrimidine derivatives are an important class of N-heterocycles. They are well-known for their wide spectrum of promising biological activities such as antitumors, bactericidals, and fungicidal.Electric Literature of C8H10N2O2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia