In 1970,Journal of the Chemical Society [Section] C: Organic included an article by Brown, Desmond J.; Sugimoto, T.. Application of 30561-07-0. The article was titled 《Aza analogs of pteridine. II. Novel use of silver oxide in transetherification of alkoxy-1,2,4,6,8-pentaazanaphthalenes, alkoxynitropyrimidines, and related systems》. The information in the text is summarized as follows:
Alkoxy derivatives of 1,2,4,6,8-pentaazanaphthalene (pyrimido[5,4-e]-as-triazine) (I) undergo transetherification when treated with boiling alcs. in the presence of silver oxide. Appropriate methoxy compounds give 5-ethoxy-3-methyl-, 5-propoxy-3-methyl-, and (more slowly) 5-isopropoxy-3-methyl-pentaazanaphthalene; also 5,7-diethoxy-, 5,7-dipropoxy-, 5,7-diisopropoxy-, 5,7-diethoxy-3-methyl-, and 5-ethoxy-3,7-di-methylpentaazanaphthalene. Synthetic routes to the methoxy substrates and to one of the products are reported; other structures are confirmed by uv and 1H NMR spectra. 4-Methoxypteridine undergoes transetherification similarly but simple alkoxypyrimidines and alkoxypyridines are resistant. However, the more highly activated 2-methoxy-5-nitro-, 4-methoxy-5-nitro-, and 2,4-dimethoxy-5-nitropyrimidine easily give their resp. propoxy homologs, and so does 2-methoxy-3,5-dinitropyridine. In contrast, 2,4-dimethoxy-6-methyl-5-nitropyrimidine gives only its 4-methoxy-2-propoxy homolog, and both 4,6-dimethoxy-5-nitro- and 4-methoxy-2,6-dimethyl-5-nitropyrimidine remain unchanged. The classical transetherification agent, ethanolic EtONa, reacts with 5,7-dimethoxypentaazanaphthalene to give the 7-ethoxy-5-hydroxy analog. This was identified by spectral comparison with its 5-hydroxy-7-methoxy homolog, itself synthesized by 5,6-addition of methanethiol to 7-methoxy-pentaazanaphthalene followed by dehydrogenation and selective hydrolysis. In the part of experimental materials, we found many familiar compounds, such as 2,4-Dimethoxy-5-nitropyrimidine(cas: 30561-07-0Application of 30561-07-0)
2,4-Dimethoxy-5-nitropyrimidine(cas: 30561-07-0) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Application of 30561-07-0
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia