Budesinsky, Zdenek published the artcileNucleophilic substitutions in the 2-methane sulfonylpyrimidine series, Recommanded Product: 5-Chloro-2-(methylthio)pyrimidine, the main research area is pyrimidine methanesulfonyl methoxide; methoxy cyano pyrimidine; sweet taste pyrimidine; oxidation methylthiopyrimidine.
Oxidation of 5-substituted 2-methylthiopyrimidines gave the 2-methylsulfonyl derivatives, the nucleophilic substitution of which with NaOMe, N2H4, PhCH2NH2, NaCN, NaSH, and NaCH(CN)CO2Me gave the appropriate 5-substituted 2-methoxy-, 2-mercapto-, 2-hydrazino, 2-benzylamino-, 2-cyano-, and 2-(methoxycarbonylcyano-methyl)pyrimidine. 2-Methylsulfonyl-5-fluoropyrimidine (I) treated at 0° with NaOMe gave 2-methoxy-5-fluoropyrimidine but at a higher temperature and with excess NaOMe, 2,5-dimethoxypyrimidine was formed. I and N2H4 gave 5-hydrazino-2-meth-ylsulfonylpyrimidine. 5-Benzylamino-2-methylsulfonylpyri-midine was prepared analogously. At 10-20°, the reaction of 2 methylsulfonyl-5-halo(fluoro, chloro, bromo)pyrimidines with-NaCN gave the 2-cyano derivatives but at a higher temperature, 2-cyano-5-methylsulfonylpyrimidine was formed. 2-Cyano-5-methylpyrimidine, 2-cyano-5-methoxypyrimidine, 2-cyano-5-fluoropyrimidine, 2-cyano-5-chloropyrimidine, and 2-cyano-5-bromopyrimidine exhibited an intensive sweet taste.
Collection of Czechoslovak Chemical Communications published new progress about Substitution reaction. 38275-42-2 belongs to class pyrimidines, name is 5-Chloro-2-(methylthio)pyrimidine, and the molecular formula is C5H5ClN2S, Recommanded Product: 5-Chloro-2-(methylthio)pyrimidine.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia