On September 12, 2003, Cadilla, Rodolfo; Henke, Brad Richard; Lambert, Millard H., III; Liu, Guangcheng Kevin; Smith, Jennifer Susan published a patent.Safety of 2-Chloro-5-isopropylpyrimidine The title of the patent was Preparation of phenoxyalkanoic acid derivatives as hPPAR activators for treatment of diabetes and cardiovascular diseases. And the patent contained the following:
Title compounds I [wherein R1 and R2 = independently H, F, CF3, or alkyl; or CR1R2 = cycloalkyl; R3 = (un)substituted heteroaryl; R4 and R5 = independently H, (perfluoro)alkyl, (perfluoro)alkoxy, halo, or CN; R6 = (un)substituted Ph or heteroaryl; R7 and R8 = independently H, F, CF3, or alkyl with the proviso that the C to which R7 and R8 are bonded is either meta or para to the depicted O; m and n = independently 1-2; or pharmaceutically acceptable salts, solvates, acid isosteres, or hydrolyzable esters thereof] were prepared as human peroxisome proliferator activated receptor (hPPAR) activators (no data). For example, Me 2-[4-[2-[[2,4-bis(trifluoromethyl)benzyl]amino]ethyl]phenoxy]-2-methylpropanoate was coupled with 2-chloro-5-ethylpyrimidine using DIEA in toluene to give the tertiary amine (38%). Hydrolysis of the ester with NaOH provided II (48%). Methods for treating diseases or conditions associated with hPPARα, hPPARγ, or hPPARδ, such as diabetes and cardiovascular diseases, comprising administration of a therapeutically effective amount of I or a pharmaceutical composition comprising I are also disclosed (no data). The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Safety of 2-Chloro-5-isopropylpyrimidine
The Article related to phenoxyalkanoic acid preparation ppar activator antidiabetic cardiovascular agent, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Safety of 2-Chloro-5-isopropylpyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia