《Nucleophilic heteroaromatic substitution. XXIV. Kinetics of piperidinodechlorination of 2- and 6-alkyl-4-choropyrimidines in ethanol and toluene. Evidence for a steric hindrance to solvation of the aza-group》 was written by Calligaris, Mario; Linda, Paolo; Marino, Gianlorenzo. Recommanded Product: 2-tert-Butyl-4-chloropyrimidine And the article was included in Tetrahedron in 1967. The article conveys some information:
The rate constant for the reaction of 2- and 6-alkyl-4-chloropyrimidines with piperidine in toluene and ethanol have been determined at 30.0°. The reactivity ratio kMe/ktert-Bu increases considerably in passing from the reaction of 6-alkyl-4-chloropyrimidines (I) in toluene (1.62) to the reaction of 2-alkyl-4-chloropyrimidines in ethanol (17.3). This remarkable increase (over a factor of ten) is ascribed to a steric hindrance to solvation of the azo groups caused by the bulkier substituent. 26 references. After reading the article, we found that the author used 2-tert-Butyl-4-chloropyrimidine(cas: 18436-67-4Recommanded Product: 2-tert-Butyl-4-chloropyrimidine)
2-tert-Butyl-4-chloropyrimidine(cas: 18436-67-4) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Recommanded Product: 2-tert-Butyl-4-chloropyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia