One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 150728-13-5, Name is 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2′-bipyrimidine, formurla is C15H10Cl2N4O2. In a document, author is Yakout, El-Sayed M. A., introducing its new discovery. HPLC of Formula: C15H10Cl2N4O2.
Bioactive Small Molecules Having a Fatty Residue. Part VI: Synthesis, Cytotoxicity Evaluation, and Molecular Docking Studies of New Pyrimidine Derivatives as Antitumor Agents
Difficultly accessible pyrimidine, thiazolopyrimidine, triazolopyrimidine, and thiazinopyrimidine derivatives containing an oleyl residue were synthesized via alkylation of 6-oleyl-2-thiouracil. The structure of the synthesized compounds was established on the basis of their spectral data, elemental analyses, and chemical behavior. The in vitro cytotoxicity of selected compounds was screened against two human cancer cell lines, MCF-7 breast cancer and HepG2 liver cancer cell lines. 8-[(8Z)-Heptadec-8-en-1-yl)-3-hydroxy-3,4-dihydropyrimido[2,1-b][1,3]thiazin-6(2H)-one turned out to be the most potent with IC50 values of 12.5 and 20 mu g/mL against MCF-7 and HepG2 cancer cell lines, respectively. The structure-activity relationship for this compound was interpreted in terms of molecular docking and molecular dynamics studies.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 150728-13-5 help many people in the next few years. HPLC of Formula: C15H10Cl2N4O2.
Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia