On February 4, 2010, Carpenter, Andrew J.; Fang, Jing; Peckham, Gregory published a patent.Reference of 2-Chloro-5-isopropylpyrimidine The title of the patent was Pyridazinyl derivatives as GPR119 agonists and their preparation and use in the treatment of metabolic disorders. And the patent contained the following:
The invention relates to compounds of formula I that are useful in the treatment of metabolic disorders, particularly type II diabetes mellitus and related disorders, and also to the methods for the making and use of such compounds Compounds of formula I wherein R1 is C1-3 alkyl and halo; A is (un)substituted phenylene, (un)substituted pyridinyl and (un)substituted pyrazinyl; R3 is H, C1-5 alkyl and C3-7 cycloalkyl; R4 is COCOR5, CO2R5, COR5, SO2C1-5 alkyl, SO2NH2 and derivatives, etc.; R5 is C1-5 alkyl and C3-7 cycloalkyl, Ph, phenyl-C1-4 alkylene, 3- to 7-membered heterocyclic ring and (un)substituted C1-5 alkyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their GPR119 agonistic activity. The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).Reference of 2-Chloro-5-isopropylpyrimidine
The Article related to pyridazinyl derivative preparation gpr119 agonist treatment metabolic disorder, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Reference of 2-Chloro-5-isopropylpyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia