Formula: C5H5ClN2O2In 2019, Noikham, Medena;Yotphan, Sirilata published 《Copper-Catalyzed Regioselective Direct C-H Thiolation and Thiocyanation of Uracils》. 《European Journal of Organic Chemistry》published the findings. The article contains the following contents:
A novel copper-catalyzed direct C-H thiolation and thiocyanation of uracils using disulfides and thiocyanate salts resp. as coupling partners are described. These reactions enable the C-H bond cleavage and C-S bond formation to proceed efficiently under relatively mild conditions, providing useful methods for a preparation of a series of thio-substituted at the C5 position of uracil derivatives These protocols exhibit several merits including simple exptl. procedures, readily accessible substrates and reagents, broad scopes, high yields, and excellent regioselectivity. Preliminary mechanistic studies revealed that a radical pathway is likely to be involved. To complete the study, the researchers used 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) .
6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Formula: C5H5ClN2O2) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia