Category: 1004-38-2

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1004-38-2, name is 2,4,6-Triaminopyrimidine, the common compound, a new synthetic route is introduced below. Computed Properties of C4H7N5

Electronic balance accurate weighing 0.10mmol of 2, 4, 6 – triaminopyrimidine, add 5 ml of anhydrous ethanol is dissolved, then said electronic balance accurate 0.10mmol of tetrachloro phthalic acid for 5 ml de-ionized water dissolves, two kinds of solution in 25 ml beaker in put into the cradle in the mixing about 30min left to shake thoroughly, completely dissolved solution (if there is a solid should be filtering to obtain the supernatant), will be small beaker sealing film for sealing, and needle push rods 15 a, at room temperature experiment table standing, make it slow volatilization; waiting for a period of about fifteen days will be colorless, transparent can in the X – ray diffraction on bulk crystals of the analysis, the remainder of the solution in the beaker for washing, to be the resulting products after drying, carried out under the optical microscope to select, to find suitable for X – ray analysis of crystal, the compound of the formula C12 H9 Cl4 N5 O4 .

The synthetic route of 1004-38-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Yantai Shimide Jidian Installations To Make Co., Ltd.; Liu Tingting; (4 pag.)CN106699673; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1004-38-2, name is 2,4,6-Triaminopyrimidine, the common compound, a new synthetic route is introduced below. Computed Properties of C4H7N5

Electronic balance accurate weighing 0.10mmol of 2, 4, 6 – triaminopyrimidine, add 5 ml of anhydrous ethanol is dissolved, then said electronic balance accurate 0.10mmol of tetrachloro phthalic acid for 5 ml de-ionized water dissolves, two kinds of solution in 25 ml beaker in put into the cradle in the mixing about 30min left to shake thoroughly, completely dissolved solution (if there is a solid should be filtering to obtain the supernatant), will be small beaker sealing film for sealing, and needle push rods 15 a, at room temperature experiment table standing, make it slow volatilization; waiting for a period of about fifteen days will be colorless, transparent can in the X – ray diffraction on bulk crystals of the analysis, the remainder of the solution in the beaker for washing, to be the resulting products after drying, carried out under the optical microscope to select, to find suitable for X – ray analysis of crystal, the compound of the formula C12 H9 Cl4 N5 O4 .

The synthetic route of 1004-38-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Yantai Shimide Jidian Installations To Make Co., Ltd.; Liu Tingting; (4 pag.)CN106699673; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1004-38-2, Adding some certain compound to certain chemical reactions, such as: 1004-38-2, name is 2,4,6-Triaminopyrimidine,molecular formula is C4H7N5, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1004-38-2.

General procedure: A mixture of 2,4,6-triaminopyrimidine 1 (1.0 mmol), 3-(2-cyanoacetyl)indole 2 (1.0 mmol), appropriate aromatic aldehyde (1.0 mmol) and indium chloride (0.05 mmol) in ethanol (5.0 mL) were subjected to microwave irradiation for 10 min at 120 C. After completion of the reaction (monitored by TLC using a dichloromethane-ethanol (9:1) mixture as the mobile phase), the reaction mixture was cooled and filtered. The solid product obtained was initially washed with ethanol, and finally recrystallized from ethanol.

According to the analysis of related databases, 1004-38-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Enriz, Ricardo D.; Tosso, Rodrigo D.; Andujar, Sebastian A.; Cabedo, Nuria; Cortes, Diego; Nogueras, Manuel; Cobo, Justo; Vargas, Didier F.; Trilleras, Jorge; Tetrahedron; vol. 74; 49; (2018); p. 7047 – 7057;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1004-38-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1004-38-2, name is 2,4,6-Triaminopyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 1 2,4-Diamino-6-(carboxaldehyde)pyrido[2,3-d]pyrimidine (III; Y=CHO) Phosphorus oxychloride (27.5 ml, 46.0 g, 300 mmol) was added over 15 minutes with stirring to N,N-dimethylformamide (11.0 g, 150 mmol), which was cooled with an ice bath. After stirring at room temperature for 1 hour, the reaction mixture was treated with bromoacetic acid (13.9 g, 100 mmol). The resulting solution, protected by a calcium chloride tube was heated at 92 C. for 10 hours and evaporated to dryness in vacuo. The colored oil (~30 g) was dissolved in water (1000 ml), and the solution was neutralized with 50% sodium hydroxide to pH 7. After addition of 2,4,6-triaminopyrimidine (5.00 g, 40.0 mmol), the solution was refluxed for 3 hours and filtered hot through a fluted filter. The filtrate was cooled and the solid that precipitated was collected by filtration and dried in vacuo over P2 O5: yield, 2.53 g (33%). Mass spectrum, m/e 189 (M+). HPLC [0.1M NH4 OAc (pH 3.6)–CH3 OH (9:1)] indicated that this product was 86% pure. A sample (200 mg) was dissolved in 0.1N HCl (15 ml) and diluted with acetone (225 ml) to precipitate impure III (Y=CHO): yield, 91 mg. The filtrate was evaporated to dryness under reduced pressure and the residue was dried in vacuo over P2 O5 to give Compound III (Y=CHO): yield, 128 mg; mp, gradual darkening and decomposition with white sublimate when taken to 360 C. lambdamax nm (epsilon*10-3): 0.1N HCl-258 (16.4), 317 (9.12), 326 sh (8.24); pH 7-263 (15.0), 316 (10.1), 345 (10.8); 0.1N NaOH-254 (13.2), 267 (13.5), 316 (8.56), 347 (10.0). 1 H-NMR (CF3 CO2 D, 6% w/v), 9.48 s, 9.75 s (5-CH, 7-CH), 10.21 s (6-CHO). Anal. Calcd for C8 H7 N5 O.HCL.1.3H2 O: C, 38.57; H, 4.30; N, 28.12. Found: C, 38.44; H, 4.15; N, 28.14.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1004-38-2, 2,4,6-Triaminopyrimidine.

Reference:
Patent; Southern Research Institute; US4526964; (1985); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1004-38-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1004-38-2 as follows.

General procedure: To a 10 ml of ethanol-H2O mixed solution containing H2NPA(0.20 mmol) and TAPI (0.10 mmol) was stirred for half an hourcontinually. The resulting clear solution was evaporated at20e25 C, and an irregular, colorless bulk crystal was obtained afterseven days. The resulting crystals were filtered and dried afterrinsed with ethanol-H2O mixed solution. Yield: 70%. Analysiscalculated for C12H14N6O7: C, 40.64; H, 3.95; N, 23.71%. Found: C,40.35; H, 4.00; N, 23.51%. Infrared spectrum (KBr disc, cm1):3441s, 3409s, 3208m, 3082m, 2416w, 1679s, 1651s, 1607s, 1569s,1538s, 1454m, 1431m, 1413m, 1351s, 1261m, 1155m, 1133w, 1077w,972w, 912m, 843w, 830m, 810m, 782s, 763m, 705s, 661w, 587m,532s.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1004-38-2, its application will become more common.

Reference:
Article; Xing, Peiqi; Li, Qingyun; Li, Yingying; Wang, Kunpeng; Zhang, Qi; Wang, Lei; Journal of Molecular Structure; vol. 1136; (2017); p. 59 – 68;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1004-38-2 ,Some common heterocyclic compound, 1004-38-2, molecular formula is C4H7N5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In some exemplary embodiments, 65 mL of concentrated hydrochloric acid was added to a solution of 5.0 g, 0.036 mol ortho-nitroaniline in 75 mL dimethyl formamide dropwise. The solution was stirred for 10 minutes at 3 C. 2.5 g, 0.036 mol of sodium nitrite in 18 mL of water was added dropwise to the solution. The resulting clear yellow solution was stirred for 30 minutes at 3 C. 4.53 g, 0.036 mol of 2,4,6-triaminopyrimidine was added in portions over 5 minutes. Orange/red precipitate forms with each addition of pyrimidine. 100 mL of water was added. The resulting orange/yellow heterogeneous mixture was gradually warmed to room temperature for approximately 20 hours with vigorous stirring. Filtration of the resulting orange slurry gave an HCl salt of azo, which was washed with ice-chilled water. The resulting pasty material was stirred vigorously with 450 mL of 10% potassium carbonate for 30 minutes at room temperature. The resulting red precipitate was filtered, washed with water, and air dried over several days or dried in a vacuum oven at 70 C. and 25 mmHg to give a yield of 8.86 g (90%) azo. The material was characterized as follows: mp 274 C. (broad dec); 1H NMR (300 MHz, DMSO-d6) delta 9.54 (s, 1H), 8.23 (dd, J=8.4, 0.9 Hz, 1H), 7.89-7.80 (m, 2H), 7.62 (td, J=8.4, 1.2 Hz, 1H), 7.34 (m, 2H), 7.01 (s, 1H), 6.74 (s, 2H); 13C NMR (75 MHz, DMSO-d6) delta 165.0, 164.5, 155.8, 145.9, 145.5, 133.7, 126.8, 124.7, 118.4, 113.0; IR: 3505, 3392, 3096, 1666, 1619, 1569, 1510, 1435, 1351, 1257, 1215 cm-1; MS-DART ionization-positive (m/z): calculated for C10H11N8O2 [M+H]+, 275.1005; found, 275.0970. Anal. Calcd. for C10H10N8O2: C, 43.80; H, 3.68; N, 40.86; Found: C, 42.68; H, 3.58; N, 39.20.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1004-38-2, 2,4,6-Triaminopyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; The United States of America as Represented by the Secretary of the Navy; US8273877; (2012); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1004-38-2, name is 2,4,6-Triaminopyrimidine, molecular formula is C4H7N5, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyrimidines

General procedure: A mixture of 2,4,6-triaminopyrimidine 1 (1.0 mmol), 3-(2-cyanoacetyl)indole 2 (1.0 mmol), appropriate aromatic aldehyde (1.0 mmol) and indium chloride (0.05 mmol) in ethanol (5.0 mL) were subjected to microwave irradiation for 10 min at 120 C. After completion of the reaction (monitored by TLC using a dichloromethane-ethanol (9:1) mixture as the mobile phase), the reaction mixture was cooled and filtered. The solid product obtained was initially washed with ethanol, and finally recrystallized from ethanol.

With the rapid development of chemical substances, we look forward to future research findings about 1004-38-2.

Reference:
Article; Enriz, Ricardo D.; Tosso, Rodrigo D.; Andujar, Sebastian A.; Cabedo, Nuria; Cortes, Diego; Nogueras, Manuel; Cobo, Justo; Vargas, Didier F.; Trilleras, Jorge; Tetrahedron; vol. 74; 49; (2018); p. 7047 – 7057;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1004-38-2 , The common heterocyclic compound, 1004-38-2, name is 2,4,6-Triaminopyrimidine, molecular formula is C4H7N5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of 2,4,6-triaminopyrimidine 1 (1.0 mmol), 3-(2-cyanoacetyl)indole 2 (1.0 mmol), appropriate aromatic aldehyde (1.0 mmol) and indium chloride (0.05 mmol) in ethanol (5.0 mL) were subjected to microwave irradiation for 10 min at 120 C. After completion of the reaction (monitored by TLC using a dichloromethane-ethanol (9:1) mixture as the mobile phase), the reaction mixture was cooled and filtered. The solid product obtained was initially washed with ethanol, and finally recrystallized from ethanol.

The synthetic route of 1004-38-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Enriz, Ricardo D.; Tosso, Rodrigo D.; Andujar, Sebastian A.; Cabedo, Nuria; Cortes, Diego; Nogueras, Manuel; Cobo, Justo; Vargas, Didier F.; Trilleras, Jorge; Tetrahedron; vol. 74; 49; (2018); p. 7047 – 7057;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1004-38-2 , The common heterocyclic compound, 1004-38-2, name is 2,4,6-Triaminopyrimidine, molecular formula is C4H7N5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of 2,4,6-triaminopyrimidine 1 (1.0 mmol), 3-(2-cyanoacetyl)indole 2 (1.0 mmol), appropriate aromatic aldehyde (1.0 mmol) and indium chloride (0.05 mmol) in ethanol (5.0 mL) were subjected to microwave irradiation for 10 min at 120 C. After completion of the reaction (monitored by TLC using a dichloromethane-ethanol (9:1) mixture as the mobile phase), the reaction mixture was cooled and filtered. The solid product obtained was initially washed with ethanol, and finally recrystallized from ethanol.

The synthetic route of 1004-38-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Enriz, Ricardo D.; Tosso, Rodrigo D.; Andujar, Sebastian A.; Cabedo, Nuria; Cortes, Diego; Nogueras, Manuel; Cobo, Justo; Vargas, Didier F.; Trilleras, Jorge; Tetrahedron; vol. 74; 49; (2018); p. 7047 – 7057;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 1004-38-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1004-38-2, name is 2,4,6-Triaminopyrimidine, molecular formula is C4H7N5, molecular weight is 125.13, as common compound, the synthetic route is as follows.

General procedure for thiocyanation of aminopyrimidine derivatives: Ammonium thiocyanate (3 mmol) and iodine (1.0 mmol) are added at room temperature to a stirred solution of the corresponding aminopyrimidine derivative (1.0 mmol) in methanol (10 mL). After completion of the reaction (TLC control), a sodium thiosulfate solution [20% (w/v)] is added to destroy the remaining iodine. The solid formed is filtered off, washed with water, and recrystallized from a methanol/water solution. For more details see Table 1 and Supplementary data.

Statistics shows that 1004-38-2 is playing an increasingly important role. we look forward to future research findings about 2,4,6-Triaminopyrimidine.

Reference:
Article; Rodriguez, Ricaurte; Camargo, Patricia; Sierra, Cesar A.; Soto, Carlos Y.; Cobo, Justo; Nogueras, Manuel; Tetrahedron Letters; vol. 52; 21; (2011); p. 2652 – 2654;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia