Category: 1004-38-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1004-38-2, name is 2,4,6-Triaminopyrimidine. A new synthetic method of this compound is introduced below., Quality Control of 2,4,6-Triaminopyrimidine

A mixture of 2,4,6-triaminopyrimidine 1 (1.0 mmol), 3-(2-cyanoacetyl)indole 2 (1.0 mmol), appropriate aromatic aldehyde (1.0 mmol) and indium chloride (0.05 mmol) in ethanol (5.0 mL) were subjected to microwave irradiation for 10 min at 120 C. After completion of the reaction (monitored by TLC using a dichloromethane-ethanol (9:1) mixture as the mobile phase), the reaction mixture was cooled and filtered. The solid product obtained was initially washed with ethanol, and finally recrystallized from ethanol. 4.2.1. 2,4-Diamino-7-(1H-indol-3-yl)-5-phenyl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile (4a) White solid; Yield: 86%; [Found: C, 69.7; H, 4.5; N, 25.9. C22H17N7 requires C, 69.6; H, 4.5; N, 25.8%]; mp 294-301 C; IR(KBr, cm-1): 3494, 3427, 3392, 3280, 3120 (NH, NH2), 2192 (C N),1622 (C=N); dH (400 MHz, DMSO-d6) 4.78 (1H, s, H-5), 5.72 (2H, s, 2-NH2), 6.00 (2H, s, 4-NH2), 7.07 (1H, t, J 7.5 Hz, indolyl-H), 7.16 (1H, t, J 7.5 Hz, indolyl-H), 7.24 (1H, t, J 7.2 Hz, Ar-H), 7.34 (2H, t, J 7.5 Hz, Ar-H), 7.41 (2H, d, J 7.1 Hz, Ar-H), 7.43 (1H, d, J 7.6 Hz, indolyl-H), 7.46 (1H, d, J 8.1 Hz, indolyl-H), 7.73 (1H, d, J 2.4 Hz, indolyl-H), 9.32 (1H, s, 8-NH), 11.65 (1H, s, indolyl-NH); dC (100 MHz, DMSO-d6) 38.6, 81.5, 85.6, 107.9, 112.0, 119.7, 119.8, 121.8, 125.1, 126.7, 127.0, 127.5, 128.4, 135.9, 145.1, 145.9, 154.6, 161.7, 161.9; m/z (rel. int. %): 379 (6, M+), 303 (20), 302 (100), 260 (11); HRMS (ESI-QTOF positive ionization): MH+ found 380.1615. C22H17N7 requires 380.1618.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1004-38-2, 2,4,6-Triaminopyrimidine.

Reference:
Article; Enriz, Ricardo D.; Tosso, Rodrigo D.; Andujar, Sebastian A.; Cabedo, Nuria; Cortes, Diego; Nogueras, Manuel; Cobo, Justo; Vargas, Didier F.; Trilleras, Jorge; Tetrahedron; vol. 74; 49; (2018); p. 7047 – 7057;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1004-38-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1004-38-2, name is 2,4,6-Triaminopyrimidine, molecular formula is C4H7N5, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of 2,4,6-triaminopyrimidine 1 (1.0 mmol), 3-(2-cyanoacetyl)indole 2 (1.0 mmol), appropriate aromatic aldehyde (1.0 mmol) and indium chloride (0.05 mmol) in ethanol (5.0 mL) were subjected to microwave irradiation for 10 min at 120 C. After completion of the reaction (monitored by TLC using a dichloromethane-ethanol (9:1) mixture as the mobile phase), the reaction mixture was cooled and filtered. The solid product obtained was initially washed with ethanol, and finally recrystallized from ethanol.

According to the analysis of related databases, 1004-38-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Enriz, Ricardo D.; Tosso, Rodrigo D.; Andujar, Sebastian A.; Cabedo, Nuria; Cortes, Diego; Nogueras, Manuel; Cobo, Justo; Vargas, Didier F.; Trilleras, Jorge; Tetrahedron; vol. 74; 49; (2018); p. 7047 – 7057;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1004-38-2, name is 2,4,6-Triaminopyrimidine, molecular formula is C4H7N5, molecular weight is 125.13, as common compound, the synthetic route is as follows.1004-38-2

A mixture of ethyl alpha-(3,4-dimethoxybenzyl)acetoacetate (42 g) and 2,4,6-triaminopyrimidine (21 g) in diphenyl ether (120 ml) was heated at 190-230 C. for 2 hours during which time the ethanol and water formed were azeotropically removed. The reaction was cooled, and methanol (250 ml) and ethanol (50 ml) were added. The resulting solid was collected by filtration and treated with boiling water (1) to give 2,4-diamino-5-methyl-6-(3,4-dimethoxybenzyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine (26 g), m.p. 346-348 C.

Statistics shows that 1004-38-2 is playing an increasingly important role. we look forward to future research findings about 2,4,6-Triaminopyrimidine.

Reference:
Patent; Burroughs Wellcome Co.; US4512992; (1985); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

1004-38-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1004-38-2, name is 2,4,6-Triaminopyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of 2,4,6-triaminopyrimidine 1 (1.0 mmol), 3-(2-cyanoacetyl)indole 2 (1.0 mmol), appropriate aromatic aldehyde (1.0 mmol) and indium chloride (0.05 mmol) in ethanol (5.0 mL) were subjected to microwave irradiation for 10 min at 120 C. After completion of the reaction (monitored by TLC using a dichloromethane-ethanol (9:1) mixture as the mobile phase), the reaction mixture was cooled and filtered. The solid product obtained was initially washed with ethanol, and finally recrystallized from ethanol.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1004-38-2, 2,4,6-Triaminopyrimidine.

Reference:
Article; Enriz, Ricardo D.; Tosso, Rodrigo D.; Andujar, Sebastian A.; Cabedo, Nuria; Cortes, Diego; Nogueras, Manuel; Cobo, Justo; Vargas, Didier F.; Trilleras, Jorge; Tetrahedron; vol. 74; 49; (2018); p. 7047 – 7057;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1004-38-2, 2,4,6-Triaminopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1004-38-2, blongs to pyrimidines compound. 1004-38-2

General procedure: A 10 mL Schlenk tube was charged with III (0.0174 g, 0.01 mmol), N,N’-diisopropylcarbodiimide (0.504 g, 4 mmol), and 1,4-diaminobenzene (0.216 g, 2 mol) under dried argon. The resulting mixture was stirred at 25 C for 2 h. The reaction mixture was extracted with ether and filtered to give a clean solution. After removing the solvent under vacuum, the residue was recrystallized in ether to provide a white solid 25 in 99% yield.

With the rapid development of chemical substances, we look forward to future research findings about 1004-38-2.

Reference:
Article; Zhang, Xingmin; Wang, Chuanyong; Qian, Cunwei; Han, Fubin; Xu, Fan; Shen, Qi; Tetrahedron; vol. 67; 45; (2011); p. 8790 – 8799;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A common compound: 1004-38-2, name is 2,4,6-Triaminopyrimidine,molecular formula is C4H7N5, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 1004-38-2

EXAMPLE 1 2,4-Diaminopyrido[2,3-d]pyrimidine-6-carboxaldehyde (III) Phosphorus oxychloride (27.5 ml, 46.0 g, 300 mmol) was added over 15 minutes with stirring to N,N-dimethylformamide (11.0 g, 150 mmol), which was cooled with an ice bath. After stirring at room temperature for 1 hour, the reaction mixture was treated with bromoacetic acid (13.9 g, 100 mmol). The resulting solution, protected by a calcium chloride tube was heated at 92 C. for 10 hours and evaporated to dryness in vacuo. The colored oil (~30 g) was dissolved in water (1000 ml), and the solution was neutralized with 50% sodium hydroxide to pH 7. After addition of 2,4,6-triaminopyrimidine (5.00 g, 40.0 mmol), the solution was refluxed for 3 hours and filtered hot through a fluted filter. The filtrate was cooled and the solid that precipitated was collected by filtration and dried in vacuo over P2 O5: yield, 2.53 g (33%). Mass spectrum, m/e 189 (M+). HPLC [ 0.1 M NH4 OAc (pH 3.6) –CH3 OH (9:1)] indicated that this product was 86% pure. A sample (200 mg) was dissolved in 0.1 N HCl (15 ml) and diluted with acetone (225 ml) to precipitate impure III: yield, 91 mg. The filtrate was evaporated to dryness under reduced pressure and the residue was dried in vacuo over P2 O5 to give compound III:

With the rapid development of chemical substances, we look forward to future research findings about 1004-38-2.

Reference:
Patent; Southern Research Institute; US4431805; (1984); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia