Category: 1004-39-3

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1004-39-3, name is 4,6-Diaminopyrimidine-2-thiol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C4H6N4S

To a flask equipped with a magnetic stirrer added 4,6-diamino-2-mercaptopyrimidine (1.4218g, 0.01mmol). It was dissolved in 40mL of methanol and added 42mL 0.25M aqueous sodium hydroxide solution. The above aqueous solution was added to the flask and stirred for 2 hours at room temperature to give the sodium salt of a mercapto group. After completion of the reaction, vacuum distillation and vacuum drying was used overnight. The dried Mercapto sodium salt was dissolved in 60mL of N, N- dimethylformamide (DMF) and Added in Step 2) obtained 4′-(1-bromo-2-ethoxy)-4-methoxyazobenzene (3.6745g, 0.11mmol), stirred at room temperature for 24h. After completion of the reaction, ethyl acetate was added then dried overnight over anhydrous magnesium sulfate, filtered and rotary evaporated to remove residual solvent. The crude product was further purified by silica gel column chromatography and finally get a diamine containing Azo-Pyrimidine monomer

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1004-39-3, 4,6-Diaminopyrimidine-2-thiol.

Reference:
Patent; Yidun New Materials (Suzhou) Co., Ltd.; Lu, Qinghua; Tong, Faqin; (24 pag.)CN105693625; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1004-39-3, name is 4,6-Diaminopyrimidine-2-thiol, molecular formula is C4H6N4S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 1004-39-3

a 2-[[(2,3-Difluorophenyl)methyl]thio]-4,6-pyrimidinediamine 4,6-diamino-2-pyrimidinethiol (7.3 g) was dissolved in DMSO (100 ml) at room temperature under an atmosphere of nitrogen. Potassium tert-butoxide (1 M in THF, 48.3 ml) was added followed by 2,3-difluorobenzyl-bromide (10.0 g). The mixture was stirred for 2 hours at room temperature. The reaction mixture was then partitioned between ethyl acetate and ammonium chloride. The organic phase was washed with ammonium chloride (3*) and brine, then dried over magnesium sulphate and evaporated to give the subtitled product as a white solid (12.2 g) MS: APCI (+ve) 269 (M+1)

With the rapid development of chemical substances, we look forward to future research findings about 1004-39-3.

Reference:
Patent; Bonnert, Roger; Cage, Peter; Hunt, Fraser; Walters, Iain; Willis, Paul; US2003/40523; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1004-39-3, name is 4,6-Diaminopyrimidine-2-thiol. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 1004-39-3

PREPARATION 6: Synthesis of 4,6-diaminopyrimidine 167.78g of 2-mercapto-4,6-diaminopyrimidine was dissolved in 1007ml of 1.5N-aqueous sodium hydroxide solution, and the reaction solution was cooled down to 0 to 4C. To this reaction solution was slowly added dropwise 267.55g of 30% aqueous hydrogen peroxide solution. After the addition is completed, 170ml of acetic acid was slowly added dropwise to the reaction solution to precipitate the solid product which was then filtered, washed successively with 200ml of distilled water, 200ml of methanol and 400ml of diethylether and dried to obtain 185.56g of the solid product as a white powder. The solid product thus obtained was slowly added to 1L concentrated hydrochloric acid which was cooled to 0C to 4C. The reaction solution was stirred for one hour at the same temperature, warmed to room temperature and then stirred for further 8 hours. The solid product produced during the reaction was filtered, washed with 1L of acetone and 1L of diethylether and then dried to obtain 109.13g of the title compound in the form of hydrochloride salt. 109.13g of the solid thus obtained was suspended in 400ml of distilled water, and 200ml of 15% aqueous sodium hydroxide solution was then added thereto. The mixture was stirred at room temperature for one hour and filtered. The filtered solid product was washed with 400ml of ethanol and then dried to obtain 100.7g of the title compound as a white powder.

With the rapid development of chemical substances, we look forward to future research findings about 1004-39-3.

Reference:
Patent; LUCKY LTD.; EP643061; (1995); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1004-39-3, 4,6-Diaminopyrimidine-2-thiol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1004-39-3, blongs to pyrimidines compound. SDS of cas: 1004-39-3

(R)-N-(2-(5-(4-(1-((4,6-diaminopyrimidin-2-yl)thio)ethyl)-5-methylthiazol-2-yl)-2- methoxyphenoxy)ethyl)methanesulfonamide (10R) and (S)-N-(2-(5-(4-(1-((4,6- diaminopyrimidin-2-yl)thio)ethyl)-5-methylthiazol-2-yl)-2- methoxyphenoxy)ethyl)methane-sulfonamide (10S)A mixture of crude chloride F from previous step and 4,6-diamino-2-mercaptopyrimidine (112 mg, 0.86 mmol) in DMF (5 mL) was stirred at 80 C for 1 h. The solution was cooled, concentrated in vacuo and purified by flash column chromatography over silica gel (25: 1 dichloromethane: methanol) to give the couple of enantiomers 10R and 10S (178 mg, 0.35 mmol, ee 40% of 10R, 61% total yield in two steps) as a white solid. Recrystallization of the enantiomers with MeOHacetone solvent system gave the 10R with >93% ee. NMR (500 MHz, Acetone-d6) delta 7.55 (d, J= 2.0 Hz, 1H), 7.48 (dd, J= 8.5, 2.0 Hz, 1H), 7.06 (d, J= 8.5 Hz, 1H), 6.26 (br s, 1H), 5.60 – 5.55 (m, 4H), 5.37 (s, 1H), 5.30 (q, J= 7.0 Hz, 1H), 4.23 (t, J= 5.5 Hz, 2 H), 3.89 (s, 3H), 3.58 (dt, J= 5.5, 5.5 Hz, 2H), 3.05 (s, 3H), 2.52 (s, 3H), 1.74 (d, J= 7.0 Hz, 3H); 13C NMR (125 MHz, DMSO-d6) delta 168.0, 163.5 (2), 162.9, 153.6, 150.6, 147.8, 126.6, 126.2, 119.5, 1 12.3, 110.4, 79.0, 67.9, 55.7, 41.9, 36.1, 30.7, 22.2, 11.2; HRMS-ESI (m/z) [M+H]+ calcd for C20H26N6O4S3 H, 511.1256; found 51 1.1259; 10R [a]19D = +340.0 (c = 0.12 acetone) (ee = 93%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1004-39-3, its application will become more common.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; RADU, Caius G.; LI, Zheng; GIPSON, Raymond M.; WANG, Jue; SATYAMURTHY, Nagichettiar; LAVIE, Arnon; MURPHY, Jennifer M.; NATHANSON, David A.; JUNG, Michael E.; WO2015/23776; (2015); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1004-39-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1004-39-3, name is 4,6-Diaminopyrimidine-2-thiol. A new synthetic method of this compound is introduced below.

To a suspension of commercially available 4,6-diaminopyrimidine-2-thiol (5g, 35mmol) in methanol (7OmL) is added IN sodium hydroxide (35mL). The resulting solution is stirred for Ih at rt then evaporated to give a tan solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1004-39-3, 4,6-Diaminopyrimidine-2-thiol, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/22185; (2009); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1004-39-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1004-39-3, name is 4,6-Diaminopyrimidine-2-thiol. This compound has unique chemical properties. The synthetic route is as follows.

Example 4 7-Amino-2-phenyl-5-imino-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-hydrobromide A mixture of 14.2 g (0.1 mole) of 2-mercapto-4,6-diamino-pyrimidine, 30.4 g (0.115 mole) of (1,2-dibromo-ethyl)-benzene, 200 ml of dimethyl formamide and 13.8 g (0.1 mole) of potassium carbonate is stirred at 45 C. for 6 hours. The reaction mixture is cooled, the precipitate is filtered, washed with water and dried. Thus 26.0 g of the desired compound are obtained, yield 80%, m.p.: above 300 C.

According to the analysis of related databases, 1004-39-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Egis Gyogyszergyar; US4921854; (1990); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1004-39-3, name is 4,6-Diaminopyrimidine-2-thiol, molecular formula is C4H6N4S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 1004-39-3

28.4 g of 4,6-diamino-2-mercaptopyrimidine (SM) was weighed and dissolved in 100 mL of N,N-dimethylformamide.Then add 82.8 g of potassium carbonate to the system.Trifluoromethyl-iodopropane was added 179.2g,The reaction was carried out for 6 h under the conditions of a 130 C oil bath.The mixture was cooled to room temperature, and the mixture was combined with EtOAc.Recrystallization from methylene chloride gave 38.1 g of a yellow solid 2-[(3,3,3-trifluoropropyl)thio]pyrimidine-4,,6-diamino (intermediate 1),The yield was 80%.

With the rapid development of chemical substances, we look forward to future research findings about 1004-39-3.

Reference:
Patent; Changzhi Yuan Yan Pharmaceutical Technology Co., Ltd.; Zhou Jian; Cai Kun; (13 pag.)CN108440627; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1004-39-3, Adding some certain compound to certain chemical reactions, such as: 1004-39-3, name is 4,6-Diaminopyrimidine-2-thiol,molecular formula is C4H6N4S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1004-39-3.

EXAMPLE 47 N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-4-(4,6-diamino-2-pyrimidinylthio)butyramide Following a procedure similar to that described in Example 34, but using N-[4-(4-piperidinomethyl-2-pyridyloxy) -cis-2-butenyl]-4-chlorobutyramide (prepared as described in Preparation 2) and 4,6-diamino-2-mercaptopyrimidine as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as an oil in a 48% yield. Nuclear Magnetic Resonance Spectrum (CDCl3), delta ppm: 1.39-1.50 (2H, multiplet); 1.55-1.67 (4H, multiplet); 1.83-2.14 (4H, multiplet); 2.30-2.47 (6H, multiplet); 3.10 (2H, triplet, J=6.8 Hz); 3.45 (2H, singlet); 3.99-4.09 (2H, multiplet); 4.61 (2H, broad singlet); 4.92 (2H, doublet, J=6.8 Hz); 5.24 (1H, singlet); 5.63-5.72 (1H, multiplet); 5.78-5.87 (1H, multiplet); 6.12-6.23 (1H, broad); 6.72-6.79 (1H, multiplet); 6.91 (1H, doublet, J=4.4 Hz); 8.05 (1H, doublet, J=4.4 Hz). Infrared Absorption Spectrum (CHCl3) numax cm-1: 2940, 1655, 1610, 1580, 1555, 1310.

According to the analysis of related databases, 1004-39-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sankyo Company, Limited; US5616579; (1997); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1004-39-3, name is 4,6-Diaminopyrimidine-2-thiol, molecular formula is C4H6N4S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 1004-39-3

2~(pentylthio)-pyrimidine-4,6-diaminePyrimidine-4,6-diamine-2-thiol (10 g, 70.3 mmol) was dissolved in methanol (140 mL) at rt to which 70 mL of IN sodium hydroxide was added. This was followed by ?-pentyl bromide (8.5 mL, 1.1 eq) and 100 mL dimethylformamide. The reaction was then stirred at rt for 18 h. LC/MS indicated clean conversion to the desired product, and consumption of starting material. The reaction was then concentrated in vacuo to provide an oil. The crude reaction mixture was then diluted with water (200 mL) and extracted with dichloromethane (3 x 300 mL). The organic portions were combined and dried over sodium sulfate, filtered and concentrated in vacuo. The product was used without further purification; yield 14.8 g (69.7 mmol)

With the rapid development of chemical substances, we look forward to future research findings about 1004-39-3.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/113538; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1004-39-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1004-39-3 as follows.

To a flask equipped with a magnetic stirrer added 4,6-diamino-2-mercaptopyrimidine (1.4218g, 0.01mmol). It was dissolved in 40mL of methanol and added 42mL 0.25M aqueous sodium hydroxide solution. The above aqueous solution was added to the flask and stirred for 2.5 hours at room temperature to give the sodium salt of a mercapto group. After completion of the reaction, Vacuum distillation and Vacuum drying was used overnight. The dried Mercapto sodium salt was dissolved in 62mL of N, N- dimethylformamide (DMF) and Added in Step 2) obtained 4′-(1-bromo-4-butoxy)-4-cyanoazobenzene (3.9820g, 0.11mmol), stirred at room temperature for 20h. After completion of the reaction, ethyl acetate was added then dried overnight over anhydrous magnesium sulfate, filtered, Rotary evaporated to remove residual solvent. The crude product was further purified by silica gel column chromatography and finally get a diamine containing Azo-Pyrimidine monomer

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1004-39-3, its application will become more common.

Reference:
Patent; Yidun New Materials (Suzhou) Co., Ltd.; Lu, Qinghua; Tong, Faqin; (24 pag.)CN105693625; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia