Category: 1004-40-6

Electric Literature of 1004-40-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1004-40-6, name is 6-Amino-4-hydroxy-2-mercaptopyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of aminouracil (1 mmol), isatin (1 mmol), and carbonyl compound (1 mmol) in DES (1 ml) was stirred on magnetic stirrer at 70oC for nearly 35-55 min. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was poured on crushed ice.The DES remained in water and solid product was separated by filtration. The DES was recovered from the filtrate by evaporation. The recovered DES was reused three-four times with comparable yields.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1004-40-6, 6-Amino-4-hydroxy-2-mercaptopyrimidine.

Reference:
Article; Khandelwal, Sarita; Rajawat, Anshu; Tailor, Yogesh Kumar; Kumar, Mahendra; Combinatorial Chemistry and High Throughput Screening; vol. 17; 9; (2014); p. 763 – 769;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1004-40-6 ,Some common heterocyclic compound, 1004-40-6, molecular formula is C4H5N3OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 1-(bromomethyl)-4-tert-butylbenzene (2.00 ml, 9.00 mmol) in 10 mL of EtOH was added a solution of 6-amino-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (2.00 g, 12.0 mmol) in EtOH (35.0 ml, 9.00 mmol), water (4.00 ml, 9.00 mmol), and 3.45 M aqueous NaOH solution (4.00 ml, 13.0 mmol). The whole was heated at 50 C. After 16 h, LCMS showed mainly the product. The reaction was cooled down to rt and concentrated. Water was added until all solids had precipitated out of the solution. The solids were filtered off with an aid of water. White solid was obtained and was purified further by performing a column chromatography using 70:30 DCM:(90:10:1 DCM:MeOH:NH4OH). The product, 2-(4-tert-butylbenzylthio)-6-aminopyrimidin-4(3H)-one was obtained as a white solid (1.8 g, 69% yield). LCMS (ESI) Calcd for C15H19N3OS: [M]+ = 289. Found [M+H]+ = 290. The carbon shift data supported the structure of 6-amino-2-(4-tert-butylbenzylthio)pyrimidin-4(1H)-one. However, line-broadening in the 1D proton and carbon data suggested the double-bond is probably moving between the two nitrogens. Thus, 6-amino-2-(4-tert-butylbenzylthio)pyrimidin-4(1H)-one and 2-(4-tert-butylbenzylthio)-6-aminopyrimidin-4(3H)-one were in equilibrium in DMSO-d6. Proton and carbon chemical shift assignments for 2-(4-tert-butylbenzylthio)-6-aminopyrimidin-4(3H)-one in DMSO-d6 were shown below.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1004-40-6, its application will become more common.

Reference:
Article; Nguyen, Hanh Nho; Bregman, Howie; Buchanan, John L.; Du, Bingfan; Feric, Elma; Huang, Liyue; Li, Xingwen; Ligutti, Joseph; Liu, Dong; Malmberg, Annika B.; Matson, David J.; McDermott, Jeff S.; Patel, Vinod F.; Wilenkin, Ben; Zou, Anruo; McDonough, Stefan I.; Dimauro, Erin F.; Bioorganic and Medicinal Chemistry Letters; vol. 22; 2; (2012); p. 1055 – 1060;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1004-40-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1004-40-6, name is 6-Amino-4-hydroxy-2-mercaptopyrimidine. A new synthetic method of this compound is introduced below.

General procedure: Anhydrous potassium carbonate (1.3821 g, 10 mmol) and substituted phenacyl halides (10 mmol) were added in succession to a suspension of 6-substituted-2-thiouracils(10 mmol) in dry N,N-dimethylformamide (10 mL). After stirring for 3 h at room temperature, the mixture was quenched with water (100 mL) and filtered. The resulting solid was crystallized from a suitable solvent.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1004-40-6, 6-Amino-4-hydroxy-2-mercaptopyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Cai, Dong; Zhang, Zhi-Hua; Chen, Yu; Yan, Xin-Jia; Zhang, Shi-Ti; Zou, Liang-Jing; Meng, Li-Hong; Li, Fang; Fu, Bing-Jie; Medicinal Chemistry Research; vol. 25; 2; (2016); p. 292 – 302;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1004-40-6, name is 6-Amino-4-hydroxy-2-mercaptopyrimidine, the common compound, a new synthetic route is introduced below. Recommanded Product: 1004-40-6

General procedure: A mixture of aminouracil (1 mmol), isatin (1 mmol), and carbonyl compound (1 mmol) in DES (1 ml) was stirred on magnetic stirrer at 70oC for nearly 35-55 min. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was poured on crushed ice.The DES remained in water and solid product was separated by filtration. The DES was recovered from the filtrate by evaporation. The recovered DES was reused three-four times with comparable yields.

The synthetic route of 1004-40-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Khandelwal, Sarita; Rajawat, Anshu; Tailor, Yogesh Kumar; Kumar, Mahendra; Combinatorial Chemistry and High Throughput Screening; vol. 17; 9; (2014); p. 763 – 769;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 1004-40-6, Adding some certain compound to certain chemical reactions, such as: 1004-40-6, name is 6-Amino-4-hydroxy-2-mercaptopyrimidine,molecular formula is C4H5N3OS, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1004-40-6.

Ethyl iodide (12 mmol) was added dropwise into a solutionof6-amino-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(6mmol)in KOH (6.2 mmol) and then the reaction mixture was stirred atroom temperature overnight. The obtained solid was collectedby filtration, washed with petroleum ether, and then dried. The solid product was sufficiently pure to be used in the subsequentreactions without further purification. Yield: 85 %, white crys-tals (EtOH), mp 220-222 8 C (Lit.[41]218-219 8 C). n max /cm 13465 (NH), 3275-3260 (NH 2 ), 2926 (C-H aliphatic), 1659(C=O), 1571 (C=N stretching), 1453 (C=C stretching). dH(90 MHz, DMSO-d 6 ) 11.80 (s, 1H, NH(3)), 6.45 (s, 2H, NH 2 ),5.00 (s, 1H), 3.10 (q, J 18.0, 2H), 1.30 (t, J 18.0, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1004-40-6, 6-Amino-4-hydroxy-2-mercaptopyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; El-Mahdy, Ahmed F. M.; El-Sherief, Hassan A. H.; Hozien, Zainab A.; Australian Journal of Chemistry; vol. 72; 7; (2019); p. 542 – 554;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

1004-40-6 , The common heterocyclic compound, 1004-40-6, name is 6-Amino-4-hydroxy-2-mercaptopyrimidine, molecular formula is C4H5N3OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of 0.174 g of 3-methyl-1-phenyl-2-pyrazoline-5-one (1, 1.0 mmol), 0.150 g of 4-chlorobenzaldehyde (2,1 mmol), 0.160 g of 6-amino-2-thiouracil (3, 1 mmol) and 9.8 mm3 of piperidine as a catalyst (10%) in 8 cm3 of ethanol in a 100-cm3 round-bottomed flask fitted with areflux condenser was heated with stirring in an oil bath maintained at 80 C. After the complete appearance of the white solid and monitored by TLC, the reaction mixture was cooled to room temperature and resulting solid product was filtered, washed with ethanol to give products 4a-4r.

The synthetic route of 1004-40-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bayat, Mohammad; Nasri, Shima; Mohammadali, Mohammad Reza; Monatshefte fur Chemie; vol. 148; 10; (2017); p. 1833 – 1842;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

1004-40-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1004-40-6, name is 6-Amino-4-hydroxy-2-mercaptopyrimidine, molecular formula is C4H5N3OS, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Anhydrous potassium carbonate (1.3821 g, 10 mmol) and substituted phenacyl halides (10 mmol) were added in succession to a suspension of 6-substituted-2-thiouracils(10 mmol) in dry N,N-dimethylformamide (10 mL). After stirring for 3 h at room temperature, the mixture was quenched with water (100 mL) and filtered. The resulting solid was crystallized from a suitable solvent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1004-40-6, 6-Amino-4-hydroxy-2-mercaptopyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Cai, Dong; Zhang, Zhi-Hua; Chen, Yu; Yan, Xin-Jia; Zhang, Shi-Ti; Zou, Liang-Jing; Meng, Li-Hong; Li, Fang; Fu, Bing-Jie; Medicinal Chemistry Research; vol. 25; 2; (2016); p. 292 – 302;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1004-40-6, name is 6-Amino-4-hydroxy-2-mercaptopyrimidine. A new synthetic method of this compound is introduced below., 1004-40-6

General procedure: A mixture of freshly calcined K2CO3 (7.4 mmol), 2-thiouracil 2a-c (7.0 mmol), 2-(bromomethyl)-2-isoindole-1,3-dione (7.7 mmol), and anhydrous DMF (20 ml) was stirred at room temperature for 72 h. The reaction mixture was filtered, and the filtrate was evaporated to dryness. The obtained residue was taken up in 1 aqueous solution, the mixture was filtered, the filtrate was extracted with EtOAc (3¡Á50 ml), dried over MgSO4, filtered, and evaporated at reduced pressure. The solids collected by filtration were air-dried until constant mass, combined with the evaporated organic extract, and the obtained mixture was purified by preparative HPLC.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1004-40-6, 6-Amino-4-hydroxy-2-mercaptopyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Novakov, Ivan A.; Sheikin, Dmitry S.; Chapurkin, Viktor V.; Nawrozkij, Maksim B.; Babushkin, Alexande S.; Kuznetsov, Yaroslav P.; Ruchko, Evsey A.; Kachala, Vadim V.; Maryshev, Anton Yu.; Schols, Dominique; Chemistry of Heterocyclic Compounds; vol. 56; 1; (2020); p. 67 – 72; Khim. Geterotsikl. Soedin.; vol. 56; 1; (2020); p. 67 – 72,6;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1004-40-6, name is 6-Amino-4-hydroxy-2-mercaptopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. 1004-40-6

Step two, the above 2-mercapto-4-amino-6-hydroxypyridine was added to aqueous ammonia, 2-mercapto-4-amino-6-hydroxypyridine and the mass ratio of 1:15 ammonia, the ammonia concentration was 25 %, and then adding the active nickel and titanium oxide, 2-mercapto-4-amino-6-hydroxypyridine, activated nickel, titanium dioxide molar ratio of these three is 1: 4: 1.5, was heated to 90 deg.] C, refluxed for 5 hours, then take advantage of The active nickel and titanium dioxide were removed by hot filtration, cooled to room temperature, and a solid precipitated. The solid was washed with 30 ml of water and dried at 40 C to give 4-amino-6-hydroxypyrimidine in a yield of 98.4%

Statistics shows that 1004-40-6 is playing an increasingly important role. we look forward to future research findings about 6-Amino-4-hydroxy-2-mercaptopyrimidine.

Reference:
Patent; Shanghai Titan Technology Co., Ltd; Xie, Yingbo; Zhang, Qing; Zhang, Hua; Xu, Xiaobing; Luo, Guiyun; (7 pag.)CN105218554; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

1004-40-6, Adding a certain compound to certain chemical reactions, such as: 1004-40-6, 6-Amino-4-hydroxy-2-mercaptopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1004-40-6, blongs to pyrimidines compound.

General procedure: A mixture of 0.174 g of 3-methyl-1-phenyl-2-pyrazoline-5-one (1, 1.0 mmol), 0.150 g of 4-chlorobenzaldehyde (2,1 mmol), 0.160 g of 6-amino-2-thiouracil (3, 1 mmol) and 9.8 mm3 of piperidine as a catalyst (10%) in 8 cm3 of ethanol in a 100-cm3 round-bottomed flask fitted with areflux condenser was heated with stirring in an oil bath maintained at 80 C. After the complete appearance of the white solid and monitored by TLC, the reaction mixture was cooled to room temperature and resulting solid product was filtered, washed with ethanol to give products 4a-4r.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1004-40-6, its application will become more common.

Reference:
Article; Bayat, Mohammad; Nasri, Shima; Mohammadali, Mohammad Reza; Monatshefte fur Chemie; vol. 148; 10; (2017); p. 1833 – 1842;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia