Category: 10070-92-5

Application of 10070-92-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.10070-92-5, name is Pyrimidine-5-carbaldehyde, molecular formula is C5H4N2O, molecular weight is 108.0981, as common compound, the synthetic route is as follows.

To a 1L 3-neck round bottomed flask equipped with an overhead stirrer, a thermocouple, a Dean-Stark trap (about 25 mL total volume), and a condenser with a nitrogen inlet was added 400.0 g of a 2.1 weight % solution of pyrimidine-5-carboxaldehyde in dichloromethane (8.4 g, 77.7 mmole contained pyrimidine-5-carboxaldehyde) and 7.39 g of 99.0 weight % 2-aminopyridine (77.7 mmole). The reaction mixture was heated to reflux under a nitrogen blanket and 349 g of dichloromethane were removed via the Dean-Stark trap at 39-48 C and atmospheric pressure. Toluene (126 mL) was added to the reaction mixture at about 48 C, followed by 31 mg of 98.5 weight % /?ara-toluenesulfonic acid monohydrate (0.16 mmol). The resulting reaction mixture was heated to reflux and distillate removed via the Dean-Stark trap until the temperature of the reaction mixture reached 110 C, at which point an additional 40 g of distillate had been removed. 50 mL of toluene was added to the reactor and the reaction mixture was refluxed at 112-1 14 C under atmospheric pressure for about 3.75 hours with removal of water via the Dean-Stark trap. HPLC analysis of the reaction mixture indicated 94.1 area % N-(5-pyrimidinylmethylene)-2-pyridinamine.

The chemical industry reduces the impact on the environment during synthesis 10070-92-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; E I DU PONT DE NEMOURS AND COMPANY; DUMAS, Donald J.; TRAN, Loc Thanh; (24 pag.)WO2017/189339; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10070-92-5, name is Pyrimidine-5-carbaldehyde, the common compound, a new synthetic route is introduced below. Computed Properties of C5H4N2O

Example 85 3-(1-oxo-5-(((1S,2S)-2-((pyrimidin-5-ylmethyl)amino)cyclohexyl)oxy)isoindolin-2-yl)piperidine-2,6-dione (I-103) To a solution of 3-(5-(((1S,2S)-2-aminocyclohexyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione (I-15, 0.16 g, 0.184 mmol) in DMF (2 mL) was added pyrimidine-5-carbaldehyde (85-1, 0.02 mL, 0.26 mmol) and the resulting mixture was stirred at rt for 15 minutes. Sodium triacetoxyborohydride (58 mg, 0.28 mmol) was added and stirring was continued at rt for 24 h. Additional pyrimidine-5-carbaldehyde (85-1, 12 mg, 0.11 mmol) was added and the reaction mixture was stirred at rt for 15 min. Additional sodium triacetoxyborohydride (25 mg, 0.12 mmol) was added stirring was continued at rt for 1 h. Additional pyrimidine-5-carbaldehyde (85-1, 12 mg, 0.11 mmol) was added and the reaction mixture was stirred at rt for 15 minutes. Sodium triacetoxyborohydride (25 mg, 0.12 mmol) was the again added and stirring was continued at rt for 1 h. The reaction mixture was then quenched with saturated aqueous sodium bicarbonate and extracted with 20% i-PrOH in DCM (*3). The combined organic phases were passed through a phase separating column and concentrated onto Celite. The crude material was purified by silica gel chromatography eluting with 0-100% EtOAc:EtOH (v/v=3:1, with 1% Et3N as a modifier) in heptane to afford I-103 (67 mg, 0.14 mmol, 79% yield) as a white solid. MS [M+H]+=450.3. 1H NMR (400 MHz, DMSO-d6) delta 10.96 (s, 1H), 9.04 (s, 1H), 8.74 (s, 2H), 7.61 (d, J=8.3 Hz, 1H), 7.20 (s, 1H), 7.08 (d, J 8.5 Hz, 1H), 5.07 (dd, J=13.3, 5.1 Hz, 1H), 4.43-4.18 (m, 3H), 3.92-3.76 (m, 1H), 3.14-3.03 (m, 1H), 2.91 (ddd, J=17.9, 13.5, 5.3 Hz, 1H), 2.64-2.55 (m, 1H), 2.44-2.31 (m, 1H), 2.29 (s, 1H), 2.13-1.93 (m, 3H), 1.73-1.59 (m, 2H), 1.42-1.13 (m, 4H).

The synthetic route of 10070-92-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Novartis AG; ADCOCK, Claire; BONAZZI, Simone; CERNIJENKO, Artiom; LAM, Philip; LINKENS, Kathryn Taylor; MALIK, Hasnain Ahmed; THOMSEN, Noel Marie-France; VISSER, Michael Scott; US2020/17461; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 10070-92-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10070-92-5, name is Pyrimidine-5-carbaldehyde, molecular formula is C5H4N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Pyrimidine-5-formaldehyde (1.00 g, 9.25 mmol),2,4-Dimethylphenylhydrazine hydrochloride (1.60 g, 9.30 mmol)And DMF (16 mL) was added to a 100 mL single-neck round bottom flask in turn.Reaction at room temperature for 1 h,Neutralize the hydrochloride with 8 mL of saturated sodium bicarbonate solution, then add water (80 mL).A yellow solid precipitated, and the solid was filtered, washed with water (50 mL¡Á2).Dissolve in dichloromethane (20 mL), separate the layers, and collect the organic phase.The title compound was obtained as a yellow solid (1.20 g, 57.0%).

According to the analysis of related databases, 10070-92-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Chen Kangzhi; Jin Chuanfei; Luo Ming; Zhang Yingjun; (28 pag.)CN108863948; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10070-92-5, name is Pyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines

A mixture of pyrimidine-5-carboxaldehyde (2 g, 1 8.50 mmol, 1 .00 equiv) and sodium borohydride (2 g) in MeOH (100 mL) was stirred at 0 – 10C for 30 min. The reaction mixture was concentrated under vacuum and the residue was purified on a silica gel column eluted with DCM/MeOH (50: 1 ) to yield 1 .2 g (59%) of pyrimidin-5-ylmethanol as a light yellow solid. LC/MS (Method K, ESI): RT= 0.74 min, m z = 1 1 1 0 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 10070-92-5, Pyrimidine-5-carbaldehyde.

Reference:
Patent; GENENTECH,INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; BUCKMELTER, Alexandre J.; CLODFELTER, Kanl H.; DRAGOVICH, Peter; HAN, Bingsong; LIN, Jian; LIU, Xiongcai; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; YUEN, Po-Wai; ZAK, Mark; ZHANG, Yamin; ZHENG, Xiaozhang; ZHAO, Guiling; WO2013/127268; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 10070-92-5, Adding some certain compound to certain chemical reactions, such as: 10070-92-5, name is Pyrimidine-5-carbaldehyde,molecular formula is C5H4N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10070-92-5.

General procedure: A mixture of the appropriate amine (1M-3M, 2 mmol) and the appropriate aldehyde (2.2 mmol) in ethanol (10 mL) was stirred at room temperature for 8 h.

According to the analysis of related databases, 10070-92-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhang, Da-Jun; Sun, Wen-Fang; Zhong, Zhao-Jin; Gao, Rong-Mei; Yi, Hong; Li, Yu-Huan; Peng, Zong-Gen; Li, Zhuo-Rong; Molecules; vol. 19; 1; (2014); p. 925 – 939;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 10070-92-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 10070-92-5, name is Pyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

To a 10-mL round-bottom flask containing crude amine 21 (1 eq., 0.834 mmol, 248 mg) was added 5-formylpyrimidine (2.1 eq., 1.75 mmol, 189 mg), Na(OAc)3BH (2.5 eq., 2.09 mmol, 442 mg) and a stir bar. The flask was sealed with a rubber septum, evacuated under high vacuum, and backfilled with argon. The contents were suspended in anhydrous 1 ,2-dichloroethane (5 mL), and the reaction was stirred vigorously at room temperature overnight. The reaction mixture was quenched with 1 M disodium citrate (1 mL) for ~ 15 minutes, followed by extraction with dichloromethane (3 x 10 mL). The combined organic layers were dried over Na2S04, filtered, and concentrated to an amber-colored oil. The oily residue was purified by column chromatography (silica gel) using 7:3 acetone:DCM as the eluent. The pure column product (pale yellow oil) was crystallized by the addition of MTBE, followed by recrystallization from boiling MTBExyclohexane to afford 4a as an off-white solid. Yield: 54 mg (0.112 mmol, 13%). FontWeight=”Bold” FontSize=”10″ H NMR (CDCb, 400 MHz) delta 3.82 (s, 4H), 3.84 (s, 2H), 3.86 (s, 3H), 6.97 (d, J= 8.8 Hz, 2H), 7.30 (dd, J= 7.7, 0.8 Hz, 1H), 7.60 (d, J= 8.8 Hz, 2H), 7.79 (t, J = 7.8 Hz, 1H), 7.99 (s, 1H), 8.09 (dd, J= 7.8, 0.8 Hz, 1H), 8.82 (s, 4H), 9.17 (s, 2H). 13C NMR (CDCb, 100 MHz) delta 53.1, 55.4, 58.1, 114.6, 118.1, 123.5, 124.0, 128.1, 131.7, 137.7, 138.7, 141.8, 151.3, 157.6, 158.1, 160.0, 166.8. EI-MS m/z 481 ([M]+, 3%), 282 (100%,). EI- HRMS m/z calc’d for C26H23N7OS 481.1685, found 481.1676.

According to the analysis of related databases, 10070-92-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GEORGIA TECH RESEARCH CORPORATION; FAHRNI, Christoph J.; MCCALLUM, Adam M.; MORGAN, Michael Thomas; (109 pag.)WO2018/231843; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10070-92-5, name is Pyrimidine-5-carbaldehyde, molecular formula is C5H4N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C5H4N2O

To a 500 mL round bottom flask were added 150 g of a 3.4 wt% solution of 5- pyrimidinecarboxaldehyde in methanol (5.1 g, 0.047 mole contained 5-pyrimidine carboxaldehyde) and 20.9 g of a 28.2 wt% solution of sodium bisulfite in water (5.9 g, 0.057 mol contained sodium bisulfite). The resulting solution was then stirred for 30 min at ambient temperature. Most of the methanol was distilled off using a rotary evaporator at 50 C to give a light slurry, to which 40 mL of isopropyl alcohol was added. The resulting slurry was cooled down to ambient temperature and stirred overnight after which time the product was collected by filtration, washed with 15 mL of mixture of water and isopropyl alcohol (5 and 10 mL), and suction-dried at ambient temperature for 4 hours to give 16.6 g of white solid. Analysis of the product by NMR indicated 61 wt% of 5-pyrimidinecarboxaldehyde – sodium bisulfite adducts (quantitative yield from 5-pyrimidinecarboxaldehyde). ‘ H NMR (500 MHz, DMSO- d6) d 9.04 (s, 1H), 8.78 (s, 2H), 6.48 (b, 1H), 5.09 (d, J = 5.6 Hz, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 10070-92-5.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; DUMAS, Donald J.; HONG, Junbae; (65 pag.)WO2019/173173; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 10070-92-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10070-92-5, name is Pyrimidine-5-carbaldehyde. A new synthetic method of this compound is introduced below.

A mixture of the product from Preparative Example 28 (1.16 g, 4.00 mmol), pyrimidine-5-carboxaldehyde (540 mg, 5.00 mmol), and Ti(OiPr)4 (4.54 g, 16.0 mmol) in anhydrous THF (20 mL) was stirred under N2 at 50 C. for 3 hr. The mixture was cooled to 25 C., NaBH3CN (1.26 g, 20.0 mmol) was added, and the mixture was stirred at 25 C. for 30 min. The mixture was poured into 5% aqueous NaOH (500 mL), saturated aqueous NaCl (50 mL) was added, and the mixture was extracted with CH2Cl2 (3¡Á100 mL). The combined extracts were dried over Na2SO4, filtered, and the solvent was evaporated. The residue was purified by column chromatography on silica gel with CH2Cl2/MeOH/conc. aqueous NH4OH (20:1:0.1). Pale yellow solid (410 mg, 27%) was obtained. M. P. 201-203 C., LCMS: MH+=383.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10070-92-5, Pyrimidine-5-carbaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; SCHERING CORPORATION; US2004/63715; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 10070-92-5 , The common heterocyclic compound, 10070-92-5, name is Pyrimidine-5-carbaldehyde, molecular formula is C5H4N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of equimolar pyrimidine-5-carbaldehyde and 3-acetylindole in ethanol (50 mL) was refluxed for 3 h following up the drop by drop addition of 20% sodium hydroxide solution yielded(2E)-1-(1H-indol-3-yl)-3-(pyrimidine-5-yl)prop-2-en-1-one (1). On completion of the reaction, the product was achieved by pouring the reaction mixture on to the ice cooled water to yield the precipitate [53]. Yield 81%; yellow-colored crystals; m. p: 125-127 C; Anal. calc. for C15H11N3O:C 72.28%,H 4.45%, N 16.86%; found: C 72.32%, H 4.40%, N 16.91%;IR numax(cm-1): 1535 (C=N), 1610 (C=N), 1734 (C=O), 3190(NH), 2985 (CH-Ar); 1H NMR (CDCl3)delta(ppm): 7.083 (s, 1H,Ar-H), 7.142 (s, 1H, Ar-H), 7.310 (s, 1H, Ar-H), 7.371 (s,1H, Ar-H), 7.410-7.489 (d, 1H, -HC=CH-), 8.198-8.257(m, 4H, Ar-H), 8.294-8.310 (d, 1H, -HC=CH-), 10.805 (s,1H, NH); 13C NMR (CDCl3)deltappm: 121.41, 121.89, 122.33,123.10, 124.21, 124.93, 125.09, 125.48, 125.88, 126.22,126.95, 127.37, 131.47, 132.51, 174.29 (C=O); ESI-MS(m/z): [M++1] 250.25 (250.09).

The synthetic route of 10070-92-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Arshad, Mohammad; Journal of the Iranian Chemical Society; vol. 17; 6; (2020); p. 1305 – 1315;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 10070-92-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10070-92-5, name is Pyrimidine-5-carbaldehyde, molecular formula is C5H4N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of the appropriate amine (1M-3M, 2 mmol) and the appropriate aldehyde (2.2 mmol) in ethanol (10 mL) was stirred at room temperature for 8 h.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 10070-92-5, Pyrimidine-5-carbaldehyde.

Reference:
Article; Zhang, Da-Jun; Sun, Wen-Fang; Zhong, Zhao-Jin; Gao, Rong-Mei; Yi, Hong; Li, Yu-Huan; Peng, Zong-Gen; Li, Zhuo-Rong; Molecules; vol. 19; 1; (2014); p. 925 – 939;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia