Category: 100707-39-9

Application of 100707-39-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 100707-39-9, name is 2-Methyl-5-bromopyrimidine-4-carboxylic acid. A new synthetic method of this compound is introduced below.

A mixture of xylenes (5 mL) solution of compound 5-bromo-2-methyl-pyrimidine-4-carboxylic acid (350mg, 1.6mmol) was refluxed for 2 hours. After cooling, the mixture directly subjected to a silica column, petroleum ether, and then give the compound 0601-120 eluting with ethyl acetate in petroleum ether (5percent v / v) as a white solid (170mg, 61percent).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100707-39-9, its application will become more common.

Reference:
Patent; CURIS INCORPORATED; CAI, XIONG; ZHAI, HAIXIAO; LAI, CHENG-JUNG; QIAN, CHANGGENG; (290 pag.)JP2015/187145; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 100707-39-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.100707-39-9, name is 2-Methyl-5-bromopyrimidine-4-carboxylic acid, molecular formula is C6H5BrN2O2, molecular weight is 217.02, as common compound, the synthetic route is as follows.

A mixture of compound 5-bromo-2-methylpyrimidine-4-carboxylic acid (350 mg,1.6 mmol) in xylene (5 mL) was refluxed for 2 h. After cooling, the mixture was applied directly to a silica column, which was eluted with petroleum ether, then ethyl acetate in petroleum ether (5percent v/v) to give compound 0601-120 (170 mg, 61 >) as a white solid. LCMS: 173 [M+l]+, 1H NMR (400 MHz, DMSO-d6): delta 2.59 (s, 3H), 8.87 (s, 2H).

Statistics shows that 100707-39-9 is playing an increasingly important role. we look forward to future research findings about 2-Methyl-5-bromopyrimidine-4-carboxylic acid.

Reference:
Patent; CURIS, INC.; BAO, Rudi; LAI, Chengjung; QIAN, Changgeng; WO2011/130628; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia