Category: 1012785-51-1

Adding a certain compound to certain chemical reactions, such as: 1012785-51-1, 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1012785-51-1, blongs to pyrimidines compound. SDS of cas: 1012785-51-1

I0444 To a solution of 2,4-dichloro-5-iodo-7H-pyrrolo[2,3-djpyrimidine (131a) (7.2 g,23 mmoi) in thy THF (200.0 mL) was added Pyridine (1.9 mL, 22.94 nunol), Tributyiphosphane(11.5 mL, 45.87 mmoi) and DIAD (9.5 rnL, 4817 mrnoi) lrnderN2, [()-(3,4-dif1uoro phenyl)[(2S,3 S,4R,5R)-3,4,5 -trihydroxytetrahydrofuran-2-yijniethyl] 4-phenyibenzoate (I 31b) (10.1 g,2294 inmol) in dry TI-IF (100.0 mL) was added to the reaction mixture at once. The reactionmixture was stirred at 25 C fbr 2 h under N2. The mixture was concentrated in vacuum to give crude product which was purified by combi-flash eluted with CH3CN in 1-120 from 100% to90 0%to afford (R,)-[2S 3S 4R 5R) -5-(2 4dichlo1oSiodornHolo[2 3-dIprimidin–d)3 4-dihvdroxy-tetrahydrofiiran-2-yi]-(3.4-difiuorophenvi) -methyl] 4-phenyibenzoate (131 c) (6,6 g,8.9 rnmoi, 39 % yield) as a yellow solid. LCMS [M±H]: 7380.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1012785-51-1, its application will become more common.

Reference:
Patent; PRELUDE THERAPEUTICS, INCORPORATED; LUENGO, Juan; LEAL, Raul, A.; LIN, Hong; SHETTY, Rupa; (166 pag.)WO2018/85833; (2018); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1012785-51-1, 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1012785-51-1, blongs to pyrimidines compound. Application In Synthesis of 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

[00491] A mixture of 2,4-dichloro-5-iodo-7H-pyrrolo[2,3-djpyrimidine (0.66 g, 2.1 mmol, 1.0 eq), 4- methylbenzenesulfonyl chloride (0.46 g, 2.4 mmol, 1.1 eq), triethylamine (0.40 mL, 29 mmol, 1.4 eq), and DMAP (0.033 g, 0.27 mmol, 0.13 eq) in 4 mL of dichloromethane was stirred at room temperature for 1 hr. The reaction mixture was diluted with dichloromethane and washed with iN HC1 (2X), followed by a wash with saturated aqueous sodium bicarbonate. The worked-up solution was dried over MgSO4, filtered, rotary evaporated, and dried under vacuum giving 1.1 g of yellow solid as the crude 2,4-dichloro-5-iodo-7-tosyl- 7H-pyrrolo [2,3 -d]pyrimidine. LC-MS: M+H=467. 7.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1012785-51-1, its application will become more common.

Reference:
Patent; PHARMACYCLICS LLC; CHEN, Wei; JIA, Zhaozhong, J.; THOMAS, William, D.; WONE, David; (190 pag.)WO2017/205762; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1012785-51-1, name is 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, the common compound, a new synthetic route is introduced below. Recommanded Product: 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

To a mixture of 2,4-dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (5 g, 15.93 mmol) in DMF (40 mL) was added NaH (764 mg, 19.1 1 mmol, 60% purity) in one portion at 0 C under N2. The mixture was stirred at 25 C for 30 min, SEMC1 (3.19 g, 19.12 mmol, 3.39 mL) was added to the mixture at 0 C and stirred for 1.5 h at 25 C. The mixture was poured into ice-water (40 mL), extracted with EtOAc (3 chi 30 mL). The combined organic phase was washed with brine (50 mL), dried over anhydrous Na2S04, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (PE:EtOAc = 10: 1) to afford 2-[(2,4-dichloro-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl- tnmethyl-silane as a yellow solid. LCMS: RT 0.996 mm, m/z = 444 j M H | . N MR (400 MHz, DMSO): delta 8.15 (s, 1 H), 5.55 (s, 2 H), 3.49 – 3.56 (m, 2 H), 0.81 – 0.87 (m, 2 H), -0.08 (s, 9 H).

The synthetic route of 1012785-51-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DENALI THERAPEUTICS INC.; ESTRADA, Anthony A.; FENG, Jianwen A.; LYSSIKATOS, Joseph P.; SWEENEY, Zachary K.; DE VICENTE FIDALGO, Javier; (271 pag.)WO2017/87905; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia