Electric Literature of 101803-06-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 101803-06-9, name is 5-Iodo-2-methoxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
EXAMPLE 2 1-(2-Deoxy-beta-D-Ribofuranosyl)-5 -(1-propynyl)-2-pyrimidinone 31.67 g (0.13 mol) of 5-iodo-2-methoxypyrimidine, 0.73 g (2.9 mol %) of CuI and 1.02 g (1.1 mol%) of bis(triphenylphosphine)PdCl2 were suspended in 200 ml of anhydrous triethylamine (distilled over BaO) in Parr pressure bottle. The bottle was evacuated and filled with 85% propyne. The bottle was repeatedly shaken and filled with propyne until the pressure had stabilized at 20 psi, and then the mixture was shaken, in a Parr hydrogenator, for 24 hours. More propyne was added at this time shaking was continued for an additional 48 hours. On tlc (methylene chloride), there was only one major product; no starting material was observed. The mixture was diluted with methylene chloride (300 ml), washed with saturated bicarbonate solution (2*60 ml), dried over magnesium sulfate and concentrated to a minimum volume with attendant precipitation. Petroleum ether was added to the mixture and after cooling, the first crop was obtained by filtration. The filtrate was concentrated to give a second crop. Both crops were dried and sublimed at 0.3 mm Hg (max. oil bath temp. 100 C.) to yield 15.26 g (76.7%) of analytically pure, white-crystalline material, 2-methoxy-5-(1-propynyl)pyrimidine; mp 88-89.5 C.).
According to the analysis of related databases, 101803-06-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; The Research Foundation of State University of New York; US4895937; (1990); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia