Category: 10320-42-0

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.10320-42-0, name is 2-Chloro-5-nitropyrimidine, molecular formula is C4H2ClN3O2, molecular weight is 159.5306, as common compound, the synthetic route is as follows.Recommanded Product: 10320-42-0

The first step: vacuuming a dry 50 mL reaction jar with nitrogen Three times, then add 2-fluoroaniline to the reaction jar(111 mg, 1.0 mmol, 1.0 equiv), add 10.0 mL of dried acetonitrile and stir until2-fluoroaniline is completely soluble,Then 2-chloro-5-nitropyrimidine (0.1593 g, 1.0 mmol, 1.0 equiv) was added to the reaction flask. Whole mixture in nitrogenThe reaction was carried out under a gas pressure for 4-5 hours. The reaction is detected by TLC, and if the reaction of aniline is detected, it can be stopped.Stop the reaction. The experimental treatment is to drain the solution in the reaction; dissolve the solute in the reaction flask with ethyl acetate, and transfer toIn a 100 mL round bottom flask, add 2 mL (200-300 mesh) of silica gel to the round bottom flask for spin-drying (petroleum ether and acetic acid B).Ester) over silica gel in the column. Wait until the intermediate product is pale yellow crystal N-(2-fluorophenyl)-5-nitropyrimidin-2-amine (209 mg, 97% yield)rate).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10320-42-0, 2-Chloro-5-nitropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Jinan University; Feng Pengju; Chen Tianfeng; Chen Junfeng; Huang Yifeng; (25 pag.)CN108148005; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 10320-42-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10320-42-0, name is 2-Chloro-5-nitropyrimidine. A new synthetic method of this compound is introduced below.

To a stirred solution of Intermediate 2 (1 g, 4.2 mmcl) in dry DMF (10 mL), Et3N (2.3 mL, 16.8 mmcl) and 2-chloro-5-nitropyrimidine (0.74 g, 4.6 mmcl) were added at rt and the resulting mixture was stirred at 120 °C for 20 h. It was diluted with water andextracted with EtOAc. The organic layer was dried over anhydrous Na2SO4 and concentrated under vacuum. The resulting crude product was purified by flash chromatography to give the title compound (yellow solid). 1H NMR (400 MHz, DMSOd 6): 6 9.08 (s, 2H), 6.92 (s, I H), 6.85-6.83 (m, I H), 6.77 (s, I H), 5.98 (m, 2H), 3.89 (s, 4H), 3.50 (s, I H), 2.45-2.44 (m, 4H), 1.30 (br s, 3H). LCMS: (Method A) 358.0 (M+H), Rt. 3.00 mm, 94.23percent (Max).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10320-42-0, 2-Chloro-5-nitropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut Gajendra; TORONTO, Dawn, V.; CROWE, David, Malcolm; (150 pag.)WO2017/144637; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 10320-42-0, 2-Chloro-5-nitropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 10320-42-0, blongs to pyrimidines compound. HPLC of Formula: C4H2ClN3O2

EXAMPLE 47; (S)-2-(4-Chlorophenyl)-5-(2-(3-(methylamino)pyrrolidin-l-yl)pyrimidin-5-yl)-4,5- dihydropyrrolo[3,4-c]pyrazol-6(2H)-one; Example 47 A. (5)-N-Methyl- 1 -(5 -nitropyrimidin-2-yl)pyrrolidin-3 -amine; [00229] (S)-N-Methylpyrrolidin-3 -amine (286 mg, 2.86 mmol) was added to 2- chloro-5-nitropyrimidine (415 mg, 2.60 mmol) slowly (CAUTION: extreme exotherm. . .). The resulting mixture was heated at 110 0C for 10 min. After cooling down to room temperature, another portion of amine (0.100 g) was added to the reaction mixture. The resulting mixture was heated at 110 0C for 10 min. After cooling down to room temperature, the obtained black solid product (Example 47A) was used for next step without further purification. LCMS (ES): m/z 252.3 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10320-42-0, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; DEVASTHALE, Pratik; WASHBURN, William, N.; WANG, Wei; HERNANDEZ, Andres; AHMAD, Saleem; ZHAO, Guohua; WO2010/47956; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10320-42-0, name is 2-Chloro-5-nitropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 2-Chloro-5-nitropyrimidine

Step D: tert-butyl ethyl but-3~yn-1-yl(5-nitropvrimidin-2-yl)propanedioate: A suspension of NaH (60 percent, 2.5 g, 62.4 mmol) in 100 mL ofDMF was added tert-butyl ethyl but-3-yn-1-ylpropanedioate (15 g, 62.4 mmol) drop-wise at 25 oc. The mixture was stirred at 40 oc for 30minutes and 2-chloro-5-nitropyrimidine (10.0 g, 62.4 mmol) in 50 mL ofDMF was addeddropwise. The resulting suspension was stirred at 50 oc for 2 hours and diluted with 500 mL ofEtOAc. The mixture was washed with water (3 x 100 mL), brine, dried over anhydrous Na2S0430 and concentrated. The residue was purified by column chromatography (Petroleum ether :EtOAc = 10 : 1) to afford the title compound; MS m/z 364 (M+ 1)+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 10320-42-0, 2-Chloro-5-nitropyrimidine.

Reference:
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; WO2013/28474; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 10320-42-0, Adding some certain compound to certain chemical reactions, such as: 10320-42-0, name is 2-Chloro-5-nitropyrimidine,molecular formula is C4H2ClN3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10320-42-0.

o-Fluorophenol (6.71 mL) and K2C03 (12.99 g) were suspended in DMF (100 mL), after which 2-chloro-5-nitropyrimidine (10 g) was added and stirred for 8 hours at room temperature. Water was added to the reaction solution, and the resulting solid was washed with water to obtain the object compound (13.67 g).NMR2: 7.20-7.38(4H, m), 9.33(2H, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10320-42-0, 2-Chloro-5-nitropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; SHINOHARA, Tomoichi; IWATA, Shin; ARAI, Kenta; ITO, Nobuaki; SUZUKI, Masaki; (53 pag.)WO2018/221667; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 10320-42-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10320-42-0, name is 2-Chloro-5-nitropyrimidine. A new synthetic method of this compound is introduced below.

Example 7 Synthesis of 5-amino-2-chloropyrimidine Compound 40 Referring to the reaction scheme of , to 140 g (0.88 mol) of 2-chloro-5-nitropyrimidine (39) dissolved in 700 mL of EtOH was added a mixture of 1400 mL of acetic acid, 700 mL water and 197 g of iron powder (70 m mesh, <212 mum). The mixture was heated overnight at 70 C. and then cooled to r.t. and then filtered. EtOH was removed from the filtrate in vacuo, and the pH was adjusted to 8 with 12 N NaOH and the product was extracted overnight with continuous liquid-liquid extraction with EtOAc. The resulting filter cake was washed with EtOAc, and the combined EtOAc layers were washed with water, then brine, dried over magnesium sulfate, and filtered. After removal of the solvent in vacuo and recrystallization with EtOH, 97.2 g (85%) of pale brown solid product 39 was obtained. 1H NMR (DMSO-d6) delta 8.94 (s, 2H), 5.77 (brs, 2H). These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10320-42-0, its application will become more common. Reference:
Patent; KADOR, PETER F.; US2014/235858; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 10320-42-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10320-42-0, name is 2-Chloro-5-nitropyrimidine. A new synthetic method of this compound is introduced below.

Intermediate 216 2-(4-methylchroman-5-yl)oxy-5-nitro-pyrimidine [1137] [1138] 4-methyl-3,4-dihydro-2Hchromen-5-ol (Intermediate 211, 111 mg, 0.676 mmol) was dissolved in 5.0 mL of DMF. K2CO3 (140 mg, 1.01 mmol) and 2-chloro-5-nitropyrimidine (162 mg, 1.01 mmol) were added and the reaction mixture was stirred for 1 hour at room temperature. DMF was then evaporated under high vacuum and the residue was purified by flash chromatography on silica gel using cyclohexane/ethyl acetate from 1:0 to 7:3 as eluents affording the title compound (192 mg). [1139] 1H NMR (400 MHz, CDCl3) delta ppm 9.36 (2H, s), 7.21 (1H, t), 6.85 (1H, d), 6.68 (1H, d), 4.15-4.35 (2H, m), 2.90-3.02 (1H, m), 2.08-2.20 (1H, m), 1.65-1.75 (1H, m), 1.29 (3H, d).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10320-42-0, its application will become more common.

Reference:
Patent; AUTIFONY THERAPEUTICS LIMITED; Alvaro, Giuseppe; Dambruoso, Paolo; Tommasi, Simona; Decor, Anne; Large, Charles; US2013/267510; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 10320-42-0, 2-Chloro-5-nitropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 10320-42-0, blongs to pyrimidines compound. SDS of cas: 10320-42-0

A mixture of 1 ,4-diazabicyclo[3.2.2]nonane (0.87 g, 6.90 mmol), 2-chloro-5- nitro-pyrimidine (1.56 g, 6.27 mmol) and dioxane (75 ml) was stirred at room- temperature for 15 h. Aqueous sodium bicarbonate (20 ml, 10percent) was added followed by extraction with ethylacetate (3 x 20 ml). The organic phase was dried and evaporated and a yellow powder was isolated. Yield 0.86 g (55percent). Mp 135-139°C.

The synthetic route of 10320-42-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NEUROSEARCH A/S; WO2009/62987; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 10320-42-0, 2-Chloro-5-nitropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-Chloro-5-nitropyrimidine, blongs to pyrimidines compound. Quality Control of 2-Chloro-5-nitropyrimidine

Acetic acid (15 mL, 261 mmol, 8 equiv) was slowly added to a stirred mixture of iron powder (11 g, 196 mmol, 6 equiv), 2-chloro-5-nitro-pyrimidine (5.3 g, 3 3. 33 m mol, 1 e quiv), a nd m ethanol (75 mL). Note: the reaction will exotherm if the acetic acid is added rapidly. After three hours, the reaction mixture was diluted with EtOAc (300 mL), filtered through celite, and neutralized with aqueous K2CO3 (200 mL). The organic layer was separated, washed with H20 (200 mL) and brine (200 mL), dried (NA2SO4), filtered, and concentrated to give 2 as a yellow solid (2.5 g, 58%, m/z+ = 130. 1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10320-42-0, 2-Chloro-5-nitropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; CYTOKINETICS, INC.; WO2005/5382; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 10320-42-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.10320-42-0, name is 2-Chloro-5-nitropyrimidine, molecular formula is C4H2ClN3O2, molecular weight is 159.5306, as common compound, the synthetic route is as follows.

4-(5-Nitro-pyrimidin-2-yl)-1 ,4-diaza-bicvclo[3.2.2]nonane free base (Intermediate compound)A mixture of 1 ,4-diazabicyclo[3.2.2]nonane (0.87 g, 6.90 mmol), 2-chloro-5- nitro-pyrimidine (1.56 g, 6.27 mmol) and dioxane (75 ml) was stirred at room- temperature for 15 h. Aqueous sodium bicarbonate (20 ml, 10percent) was added followed by extraction with ethylacetate (3 x 20 ml). The organic phase was dried and evaporated and a yellow powder was isolated. Yield 0.86 g (55percent). Mp 135-139°C.

Statistics shows that 10320-42-0 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-5-nitropyrimidine.

Reference:
Patent; NEUROSEARCH A/S; WO2009/62989; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia