Category: 1032452-86-0

Related Products of 1032452-86-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1032452-86-0, name is 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole, molecular formula is C13H10ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-Methylbenzenesulfonic acid hydrate (8.7 g) was added in one portion to 3-(2- chloropyrimidin-4-yl)-1-methylindole (9.3 g) and 4-fluoro-2-methoxy-5-nitroaniline (7.1 g) in nbutanol (200 mL). The resulting mixture was stirred at reflux for 1 h. The mixture was cooled to room temperature. The precipitate was collected by filtration, washed with n-butanol (50 mL), and dried under vacuum to afford N-(4-fluoro-2-methoxy-5-nitrophenyl)- 4-(1- methylindol-3- yl)pyrimidin-2-amine as a yellow solid (CompoundS, 15.5 g).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1032452-86-0, 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole.

Reference:
Patent; NEUFORM PHARMACEUTICALS, INC.; CHAORAN, Huang; CHANGFU, Cheng; (85 pag.)WO2017/117070; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 1032452-86-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1032452-86-0, name is 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole. A new synthetic method of this compound is introduced below.

GB012 (0.5g, 2.06mmol) and 2-methoxy-5-nitroaniline (0.347g, 2.06mmol) were dissolved in 2-pentanol (20mL), p-toluenesulfonic acid monohydrate ( 0.471g, 2.5mmol), then heated to 105 , reacted for 2.5 hours, and finally cooled to room temperature. It was suction filtered, and the filter cake was washed with 2-pentanol (5 mL) and dried to obtain GB104 (0.37 g).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1032452-86-0, its application will become more common.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhao Yujun; Guo Dexiang; Yan Ziqin; (89 pag.)CN108069939; (2020); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1032452-86-0, name is 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole. A new synthetic method of this compound is introduced below., Product Details of 1032452-86-0

3. Synthesis of intermediate 006-5 The intermediates 006-2 (75 mg, 307.8 mmol) and 006-4 (57.4 g, 308.4 mmol), 975 mL of isopropyl alcohol, and p-toluenesulfonic acid (63.7 g, 369.9 mmol) were sequentially added into a 2 L four-necked flask under nitrogen atmosphere, and the reaction was heated and maintained at 105C for 5 h. The reaction mixture was cooled to room temperature and filtered, and the filter cake was washed with 750 mL of isopropanol three times. The filter cake was washed three times with 750 mL of acetonitrile and dried to give 75 g of the intermediate 006-5 (62%) as a yellow solid. LC-MS: 394.1.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1032452-86-0, 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole.

Reference:
Patent; Shanghai Shaletech Technology Co., Ltd.; JIANG, Yueheng; (143 pag.)EP3216786; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1032452-86-0 ,Some common heterocyclic compound, 1032452-86-0, molecular formula is C13H10ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In 80 mL of sec-butanol, 2.44 g (10.04 mmol) of compound 2, 2.60 g (15.06 mmol) of p-toluenesulfonic acid and 2.48 g (10.04 mmol) of 4-bromo-5-nitro 2-methoxyaniline were added. The mixture was reacted at 90 C for 20 hours, detected by TLC, and the reaction was completed.It cooled to room temperature, concentrated to give a black solid, which was successively washed with acetonitrile and methyl tert-butyl ether to give 2.58 g (5.68 mmol) of Compound 3 The crude yield of 56.56 %

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1032452-86-0, its application will become more common.

Reference:
Patent; Beijing Xuanyi Pharmaceutical Technology Co., Ltd.; Jilin Huikang Pharmaceutical Co., Ltd.; Song Yuntao; A .J.buliqi; (90 pag.)CN104761544; (2019); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1032452-86-0, name is 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole. This compound has unique chemical properties. The synthetic route is as follows. name: 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole

N-(5-amino-4-methoxy-2-(trifluoromethyl)phenyl)acetamide (496 mg, 2.0 mmol),3-(2-chloropyrimidin-4-yl)-1-methyl-1H-indole (704 mg, 4.0 mmol) was dissolved in 2-pentanol (10 mL),Then p-toluenesulfonic acid monohydrate (688 mg, 4.0 mmol) was added.The reaction was stirred at 130 C for 4 hours.After the reaction is over,Cool to room temperatureSaturated sodium bicarbonate (20 mL) was added to the reaction solution.Extract with dichloromethane (100 mL x 3).Combine the organic phase,The organic phase was washed with saturated brine (100 mL).Drying with anhydrous sodium sulfateConcentrate under reduced pressure,The crude product was isolated and purified by silica gel column chromatography (eluent: petroleum ether:Ethyl acetate = 2:1) gave a yellow solid (113 mg, yield: 12.4%).

With the rapid development of chemical substances, we look forward to future research findings about 1032452-86-0.

Reference:
Patent; Tianjin Binjiang Pharmaceutical Research And Development Co., Ltd.; Tian Hongqi; Huang Gongchao; Cheng Ying; (48 pag.)CN107793413; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia