Category: 1044145-59-6

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1044145-59-6, name is (4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 1044145-59-6

To a solution of (4-chloro-2-(methylthio)pyrimidin-5-yl)methanol (1.14 g, 6 mmol) in DCM (200 mL) was added MnO2 (8.7 g, 100 mmol), the reaction was stirred at r.t. overnight, then filtered, the filtrate was concentrated to give 4-chloro-2-(methylthio)pyrimidine-5-carbaldehyde as a yellow solid , which was used for the next step without purification. Yield: 72.7%, MS (m/z): 188.9 (M+1) +.

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Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-guo; DAI, Guangxiu; XIAO, Kun; JIA, Hong; ZHANG, Zhulin; VENABLE, Jennifer Diane; BEMBENEK, Scott Damian; CHAI, Wenying; WO2014/15830; (2014); A1;,
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Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1044145-59-6, name is (4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C6H7ClN2OS

Manganese(IV) oxide, <5 micron, activated (38.1g , 439 mmol) was added to a solution of compound 223 (16.73 g, 87.8 mmol) in chloroform (800 mL). The reaction was stirred overnight, filtered through Celite, and the filtrate was concentrated in vacuo to yield compound 224 (13.7 g, 82.8% yield). 1H NMR (500 MHz, CDCl3) delta 10.31 (s, 1 H) 8.88 (s, 1 H) 2.65 (s, 2 H) ppm. If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1044145-59-6, (4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol. Reference:
Patent; AMGEN INC.; WO2009/85185; (2009); A1;,
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Related Products of 1044145-59-6, Adding some certain compound to certain chemical reactions, such as: 1044145-59-6, name is (4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol,molecular formula is C6H7ClN2OS, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1044145-59-6.

To a solution of KR-i 8 (i .7 g, 9 mmol) in 0H2012 (20 mL) was added TBSCI(tert-Butyldimethylsilyl chloride) (2.0 g, i3.3 mmol), imidazole (i .2 g, i8mmol). The reaction mixture was stirred at r.t. for iO h. The reaction mixturewas quenched into water, extracted with 0H2012, dried with anhydrousNa2SO4, concentrated to give the crude product which was purified by column chromatography (eluting with PE/ EA = iOO:i to 5:i) to give the pure reagent KR-19 (2.1 g, 77.8%) as a yellow solid. ESI-MS (Mi-i): 305.1 calc. for C12H21CIN2OSSi: 304.0.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1044145-59-6, (4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FUNDACION PARA LA INVESTIGACION MEDICA APLICADA; CUADRADO TEJEDOR, Maria Del Mar; FRANCO FERNANDEZ, Rafael; GARCIA OSTA, Ana Maria; OYARZABAL SANTAMARINA, Julen; RABAL GRACIA, Maria Obdulia; WO2014/131855; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1044145-59-6, name is (4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol. A new synthetic method of this compound is introduced below., HPLC of Formula: C6H7ClN2OS

General Procedure 5-2: 4-Chloro-2-(methylthio)pyrimidine-5-carbaldehyde[00195] A mixture of (4-chloro-2-(methylthio)pyrimidin-5-yl) methanol (9.0 g, 47 mmol) and activated MnO2 (70 g, 800 mmol, Aldrich Cat. No. 217646) in 120 mL CH2Cl2 was stirred at the room temperature for 24 hours. The mixture was filtered through Celite (Acros Celite 521, Cat.No. 206350010). The filter cake was washed with CH2Cl2 until no UV-active material was seen. The combined CH2Cl2 solution was concentrated and passed through a thin silica gel plug, using 25% EtOAc/Hexanes. The filtrate was concentrated to give an off white solid (6.37 g,71.6% yield).HPLC Rt: 5.53 min.1H-NMR (CDCl3): delta 10.32 (s, IH), 8.88 (s, IH), 2.65 (s, 3H).

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Reference:
Patent; BIOGEN IDEC MA INC.; WO2008/94575; (2008); A2;,
Pyrimidine | C4H4N2 – PubChem,
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Related Products of 1044145-59-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1044145-59-6, name is (4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol, molecular formula is C6H7ClN2OS, molecular weight is 190.65, as common compound, the synthetic route is as follows.

step 2: Manganese (IV) oxide (137.4 g, 1.58 mol) was added to a solution of (4-chloro-2-(methylthio)pyrimidin-5-yl)methanol (30.0 g, 0.158 mol) in DCM (1.5 L). The reaction was stirred overnight, filtered through CELITE, and the filtrate was concentrated in vacuo to give the crude product 4-chloro-2-(methylthio)pyrimidine-5-carbaldehyde as a white solid. The crude product was purified by SiO2 chromatography eluting with PE/EA (10:1) to afford pure 4-chloro-2-(methylthio)pyrimidine-5-carbaldehyde (21.0 g, 74.1%) as a white solid. 1H NMR (400 MHz, CDCl3) delta 10.31 (s, 1H), 8.87 (s, 1H), 2.64 (s, 3H); MS: 189 [M+H]+.

Statistics shows that 1044145-59-6 is playing an increasingly important role. we look forward to future research findings about (4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol.

Reference:
Patent; GENENTECH, INC.; Rudolph, Joachim; Gazzard, Lewis J.; Crawford, James J.; Ndubaku, Chudi; Drobnick, Joy; Lee, Wendy; US2015/31674; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia