Category: 1053228-29-7

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1053228-29-7, name is 2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H2Cl2FN3, molecular weight is 206.01, as common compound, the synthetic route is as follows.Computed Properties of C6H2Cl2FN3

To a solution of 2,4-dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine (2.5 g, 12.14 mmol) in DMF (25 mL) was added NaH (582 mg, 14.57 mmol) at 0C. The mixture was stirred at this temperature for 1 h, and then SEM-C1 (2.43 g, 14.57 mmol) was added dropwise at 0C. The resulting mixture was stirred at 25C for 1 h. The reaction was slowly poured into ice-water, and then extracted with EtOAc (3 chi 80 mL). The combined organic phase was washed with brine (50 mL), dried over anhydrous Na2S04, filtered and concentrated under reduced pressure to give 2,4-dichloro-5-fluoro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine (2.5 g, 61.24% ) as a yellow oil. LCMS: RT 0.975 mm . m/z = 336.1 i H | .

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1053228-29-7, 2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; DENALI THERAPEUTICS INC.; ESTRADA, Anthony A.; FENG, Jianwen A.; LYSSIKATOS, Joseph P.; SWEENEY, Zachary K.; DE VICENTE FIDALGO, Javier; (271 pag.)WO2017/87905; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 1053228-29-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1053228-29-7, name is 2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H2Cl2FN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 2,4-dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine (0.44 g, 2.14 mmol) and N, N-Diisopropylethylamine (0.57 mL, 3.2 mmol) in s-Butanol (5 mL) was added (S)-(-)-l-Phenylethylamine (0.34 g, 2.78 mmol) at ambient temperature. The mixture was stirred at reflux for 3 hours. Solvent was removed under reduced pressure. The residue obtained was purified by flash chromatography on silica gel 1 : 1 hexane/ethyl acetate to give 2-chloro-5-fluoro-N-[(l S)-l-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine (0.45 g, 72% yield) as solid. LCMS ESI (+) m/z 291 (M+H)

According to the analysis of related databases, 1053228-29-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PELOTON THERAPEUTICS, INC.; WANG, Bin; YANG, Hanbiao; BEDKE, Karl; WEHN, Paul; RIZZI, James P.; (241 pag.)WO2018/183635; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1053228-29-7, 2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1053228-29-7, blongs to pyrimidines compound. Product Details of 1053228-29-7

To a stirred solution of 2,4-dichloro-5-fluoro-7H-pyrrolo[2,3-Patent; MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME LIMITED; GIRIJAVALLABHAN, Vinay, M.; MCLAUGHLIN, Mark; CLEATOR, Edward; KONG, Jongrock; GIBSON, Andrew William; LIEBERMAN, David, R.; DIEGUEZ VAZQUEZ, Alejandro; KEEN, Stephen Philip; WILLIAMS, Michael, J.; MOORE, Jeffrey, C.; MILCZEK, Erika, M.; PENG, Feng; BELYK, Kevin, M.; SONG, Zhiguo Jake; (70 pag.)WO2017/53216; (2017); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia